| Tag | Content |
|---|
| CPLM ID | CPLM-020801 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2 |
Protein Synonyms/Alias | 3-hydroxyacyl-CoA dehydratase 2; HACD2; Protein-tyrosine phosphatase-like member B |
Gene Name | Ptplb |
Gene Synonyms/Alias | hacd2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 251 | LSHTEEHKKFE**** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis (By similarity). |
Sequence Annotation | ACT_SITE 176 176 By similarity.
ACT_SITE 183 183 By similarity.
MOD_RES 2 2 N-acetylalanine (By similarity).
CARBOHYD 209 209 N-linked (GlcNAc...) (Potential). |
Keyword | Acetylation; Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 254 AA |
Protein Sequence | MAAAAATAAT KGNGGGSGRV GAGDSSGARK KKGPGPVATA YLVIYNVVMT AGWLVIAVGL 60
VRAYLAKGSY HSLYYSIERP LKFFQTGALL EILHCAIGIV PSSVVLTSFQ VMSRVFLIWA 120
VTHSVKEVQS EDSVLLFVIA WTITEIIRYS FYTFSLLNHL PYIIKWARYT LFIVLYPMGV 180
TGELLTIYAA LPFVRQAGLY SISLPNKYNF SFDYHAFLIL IMISYIPLFP QLYFHMIHQR 240
RKVLSHTEEH KKFE 254 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016829; F:lyase activity; IEA:UniProtKB-KW. GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |