CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014699
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat flightless-interacting protein 1 
Protein Synonyms/Alias
 LRR FLII-interacting protein 1 
Gene Name
 Lrrfip1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
105EASIREIKDSLAEVEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). 
Sequence Annotation
 REGION 479 580 DNA-binding (By similarity).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 16 16 Phosphoserine (By similarity).
 MOD_RES 83 83 Phosphoserine (By similarity).
 MOD_RES 88 88 Phosphoserine (By similarity).
 MOD_RES 91 91 Phosphothreonine (By similarity).
 MOD_RES 302 302 Phosphoserine (By similarity).
 MOD_RES 551 551 Phosphoserine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 738 AA 
Protein Sequence
MTSPEGAQNK EIDCLSPEAQ RLAEARLAAK RAARAEAREI RMKELERQQK EVEERPDKDF 60
AEKGSRNMPS LSAATLASLG GTSSRRGSGD TSISMDTEAS IREIKDSLAE VEEKYKKAMV 120
SNAQLDNEKT NFMYQVDTLK DMLLELEEQL AESQRQYEEK NKEFEREKHA HSILQFQFAE 180
VKEALRQREE MLEKHGIILN SEIATNGETS DTVNDVGYQA PTKITKEELN ALKAAGEGTL 240
GKAKEVEVKK EIVEKVGQRE TLQDSEQEQP KLNTGKDCVD RGVLHPGEKA ENQRPVEDSA 300
LSPGPLAGAK CEQEVQSQDQ ENTSILKSPE QIESHEVTNK SDSRDSNSPE PSSCRGGLDS 360
EVSGPTALGI KNQSENSMDS QGKENQEDLG KGSFEPRPDH VLGQTPEIDK VSCTDSRGTG 420
GNHLEDVVQA GDTIVEDQVG TMASAEQSKS MENHIGRSLN DGLGQSSERE LAHEAAELEE 480
ALTQSSQAGG ENTVTEAEDA AVRDEKPLQA DVQATPAAPT VQSGHQDTTG PGSTDTKHTS 540
PHAKERNKAK SEQQAEALDS PQKKTKNKKK KNKKKKAAAP METCKDANEE SSCQDPDVGD 600
GEEEERVQAT DKKWAAETPE LKEDPQSRPS GKQNDAEEDS GPAEGPTDVL DQNSLQCADG 660
DISPVGRKGP QRDASQIGGE EGLVPSQHPG QADEKGIEGH SVDNSDLSGE LGGFNSESGE 720
QAREEVGNSK SKEDCTMS 738 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR019139; Leu-rich_rep_flightless-int_pr. 
Pfam
 PF09738; DUF2051 
SMART
  
PROSITE
  
PRINTS