CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022739
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pericentriolar material 1 protein 
Protein Synonyms/Alias
 PCM-1; mPCM-1 
Gene Name
 Pcm1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
259SYMKFLQKILARENEubiquitination[1]
432SEHLPDEKVQLFSKMubiquitination[1]
438EKVQLFSKMRVLQEKubiquitination[1]
1112QNNVQRLKQMLTELMubiquitination[1]
1217TEYMAFPKPFESSSSubiquitination[1]
1229SSSLGAEKQRNQKQPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins probably including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Probably involved in the biogenesis of cilia. 
Sequence Annotation
 MOD_RES 65 65 Phosphoserine.
 MOD_RES 68 68 Phosphoserine (By similarity).
 MOD_RES 69 69 Phosphoserine.
 MOD_RES 93 93 Phosphoserine (By similarity).
 MOD_RES 110 110 Phosphoserine (By similarity).
 MOD_RES 399 399 N6-acetyllysine (By similarity).
 MOD_RES 859 859 Phosphoserine (By similarity).
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 957 957 Phosphoserine (By similarity).
 MOD_RES 1182 1182 Phosphoserine (By similarity).
 MOD_RES 1228 1228 Phosphoserine (By similarity).
 MOD_RES 1254 1254 Phosphoserine (By similarity).
 MOD_RES 1257 1257 Phosphoserine (By similarity).
 MOD_RES 1260 1260 Phosphoserine (By similarity).
 MOD_RES 1287 1287 Phosphoserine.
 MOD_RES 1432 1432 Phosphoserine.
 MOD_RES 1434 1434 Phosphoserine.
 MOD_RES 1654 1654 Phosphoserine.
 MOD_RES 1695 1695 Phosphoserine (By similarity).
 MOD_RES 1729 1729 Phosphoserine.
 MOD_RES 1766 1766 Phosphoserine.
 MOD_RES 1769 1769 Phosphoserine.
 MOD_RES 1777 1777 Phosphoserine.
 MOD_RES 1959 1959 Phosphoserine (By similarity).
 MOD_RES 1978 1978 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2025 AA 
Protein Sequence
MATGGGPFEE VMHDQDLPNW SNDSVDDRLN NMEWGGQQKK ANRSSEKNKK KFGVASDKRV 60
TNAISPESSP GVGRRRTKIP HTFPHSRYMT QMSVPEQAEL EKLKQRINFS DLDQRSIGSD 120
SQGRATAANN KRQLSENRKP FNFLPMQINT NKSKDATASL PKREMTTSAQ CKELFASALS 180
NDLLQNCQVS EEDGRGEPAM ESSQIVSRLV QIRDYITKAS SMREDLVEKN ERSANVERLT 240
HLIEHLKEQE KSYMKFLQKI LARENEEEDV RTVDSAVGSG SVAESTSLNA DVQSEASDTT 300
ARDPQQEPME ETENLKKQHD LLKRMLQQQE QLRALQGRQA ALLALQHKAE QAIAVMDDSV 360
VTETTGSLSG VSITSELNEE LNDLIQRFHN QLRDSQPPAV PDNRRQAESL SLTREISQSR 420
NPSVSEHLPD EKVQLFSKMR VLQEKKQKMD KLLGELHNLR DQHLNNSSFV PSTSLQRSGD 480
KRSSTVALSA PVGFASAVNG EANSLISSVP CPATSLVSQN ESENEGHLNP AEKLQKLNEV 540
QKRLNELREL VHYYEQTSDM MTDAVNENTK DEETEESEYD SEHENSEPVT NIRNPQVAST 600
WNEVNTNSNT QCGSNNRDGR PVNSNCEINN RSAANIRALN MPPLDCRYNR EGEQRLHVAH 660
GEDEEEEVEE EGVSGASLSS RRSSLVDEAP EDEEFEQKIS RLMAAKEKLK QLQDLVAMVQ 720
DDDATQVVVP AASNLDDFYA AEEDIKQNSN NARENSNKID TGVNEKTREK FYEAKLQQQQ 780
RELKQLQEER KKLIEIQEKI QAVQKACPDL QLSATSISSG PTKKYLPAIT STPTVNENDS 840
STSKCVIDPE DSSVVDNELW SDMRRHEMLR EELRQRRKQL EALMAEHQRR QGLAETSSPV 900
AISLRSDGSE NLCTPQQSRT EKTMATWGGS TQCALDEEGD EDGYLSEGIV RTDEEEEEEQ 960
DASSNDNFPI YPPSMNQNSY NVKETKTRWK SNRPVSADGN YRPLAKTRQQ NISMQRQENL 1020
RWVSELSYIE EKEQWQEQIN QLKKQLDFSV NICQTLMQDQ QTLSCLLQTL LTGPYSVLPS 1080
NVASPQVHLI MHQLNQCYTQ LTWQQNNVQR LKQMLTELMR QQNQHPEKPR SKERGSSASH 1140
PSSPNLFCPF SFPTQPVNLF NLPGFTNFPS FAPGMNFSPL FPSNFGDFSQ NVSTPTEQQQ 1200
PLAQNPSGKT EYMAFPKPFE SSSSLGAEKQ RNQKQPEEEA ENTKTPWLYD QEGGVEKPFF 1260
KTGFTESVEK ATNSNRKNQP DTSRRRRQFD EESLESFSSM PDPIDPTTVT KTFKTRKASA 1320
QASLASKDKT PKSKSKKRNS TQLKSRVKNI GYESASVSST CEPCKNRNRH SAQTEEPVQA 1380
KLFSRKNHEQ LEKIIKYSRS AEISSETGSD FSMFEALRDT IYSEVATLIS QNESRPHFLI 1440
ELFHELQLLN TDYLRQRALY ALQDIVSRHI SESDEREGEN VKPVNSGTWV ASNSELTPSE 1500
SLVTTDDETF EKNFERETHK VSEQNDADNV SVMSVSSNFE PFATDDLGNT VIHLDQALAR 1560
MREYERMKTE TESHSNMRCT CRVIEDEDGA AAAATVSNSE ETPIIENHNS PQPISDVSAV 1620
PCPRIDTQQL DRQIKAIMKE VIPFLKEHMD EVCSSQLLTS VRRMVLTLTQ QNDESKEFVK 1680
FFHKQLGSIL QDSLAKFAGR KLKDCGEDLL VEISEVLFNE LAFFKLMQDL DNNSIAVKQR 1740
CKRKIEAAGV RQSYAKEAKR ILEGDHGSPA GEIDDEDKDK DETETVKQTQ TSEVYDAKGP 1800
KNVRSDVSDQ EEDEESERCP VSINLSKAES QALTNYGSGE DENEDEEMED FEESPVDIQT 1860
SLQANTETTE ENEHDSQILQ HDLEKTPEST NVPSDQEPTS KNDQDSSPVK PCYLNILENE 1920
QQLNSATHKD SLTTTDSSKQ PEPLPLPLAA SETLVPRVKE VKSAQETPES SLAGSPDTES 1980
PVLVNDYEAE SGNISQKSDE EDFVKVEDLP LKLTVYSEEE LRKKMIEEEQ KNHLSGEICE 2040
MQTEELAGNS QILKEPETVG AQSI 2064 
Gene Ontology
 GO:0034451; C:centriolar satellite; IDA:BHF-UCL.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0000242; C:pericentriolar material; IDA:BHF-UCL.
 GO:0051297; P:centrosome organization; IEA:Compara.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0022027; P:interkinetic nuclear migration; IMP:BHF-UCL.
 GO:0034454; P:microtubule anchoring at centrosome; IMP:MGI.
 GO:0050768; P:negative regulation of neurogenesis; IMP:BHF-UCL.
 GO:0097150; P:neuronal stem cell maintenance; IMP:MGI.
 GO:0071539; P:protein localization to centrosome; IMP:BHF-UCL. 
Interpro
 IPR024138; Pericentriolar_Pcm1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS