CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006224
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane 9 superfamily member 1 
Protein Synonyms/Alias
 70 kDa endomembrane protein; Endomembrane protein EMP70; Protein p24a; Acidic 24 kDa late endocytic intermediate component 
Gene Name
 EMP70 
Gene Synonyms/Alias
 TMN1; YLR083C; L2385; L9449.11 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
665RKIYSSIKVD*****ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 With TMN2 and TMN3, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression. Acts downstream of RAS2 and TOR. Essential for cell adhesion and filamentous growth. 
Sequence Annotation
 CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
 CARBOHYD 282 282 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Direct protein sequencing; Endosome; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 667 AA 
Protein Sequence
MIYKMAHVQL LLLYFFVSTV KAFYLPGVAP TTYRENDNIP LLVNHLTPSM NYQHKDEDGN 60
NVSGDKENFL YSYDYYYNRF HFCQPEKVEK QPESLGSVIF GDRIYNSPFQ LNMLQEKECE 120
SLCKTVIPGD DAKFINKLIK NGFFQNWLID GLPAAREVYD GRTKTSFYGA GFNLGFVQVT 180
QGTDIEATPK GAETTDKDVE LETRNDRNMV KTYELPYFAN HFDIMIEYHD RGEGNYRVVG 240
VIVEPVSIKR SSPGTCETTG SPLMLDEGND NEVYFTYSVK FNESATSWAT RWDKYLHVYD 300
PSIQWFSLIN FSLVVVLLSS VVIHSLLRAL KSDFARYNEL NLDDDFQEDS GWKLNHGDVF 360
RSPSQSLTLS ILVGSGVQLF LMVTCSIFFA ALGFLSPSSR GSLATVMFIL YALFGFVGSY 420
TSMGIYKFFN GPYWKANLIL TPLLVPGAIL LIIIALNFFL MFVHSSGVIP ASTLFFMVFL 480
WFLFSIPLSF AGSLIARKRC HWDEHPTKTN QIARQIPFQP WYLKTIPATL IAGIFPFGSI 540
AVELYFIYTS LWFNKIFYMF GFLFFSFLLL TLTSSLVTIL ITYHSLCLEN WKWQWRGFII 600
GGAGCALYVF IHSILFTKFK LGGFTTIVLY VGYSSVISLL CCLVTGSIGF ISSMLFVRKI 660
YSSIKVD 667 
Gene Ontology
 GO:0005768; C:endosome; IDA:SGD.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0006878; P:cellular copper ion homeostasis; IMP:SGD.
 GO:0016197; P:endosomal transport; IMP:SGD.
 GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
 GO:0007124; P:pseudohyphal growth; IGI:SGD.
 GO:0007034; P:vacuolar transport; IGI:SGD. 
Interpro
 IPR004240; EMP70. 
Pfam
 PF02990; EMP70 
SMART
  
PROSITE
  
PRINTS