UniProt Accession

 Q86UY0_HUMAN; Q86UY0 

Genbank Protein ID

 AL023694; AL096800; AL133541; BC052310 

Genbank Nucleotide ID

 AAH52310.1 

Protein Name

 TXNDC5 protein 

Protein Synonyms/Alias

 Thioredoxin domain-containing protein 5; Uncharacterized protein 

Gene Name

 TXNDC5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	YNSMEDAKVYVAKVD	ubiquitination	[1]
46	DAKVYVAKVDCTAHS	ubiquitination	[2]
71	YPTLKLFKPGQEAVK	ubiquitination	[2]
78	KPGQEAVKYQGPRDF	ubiquitination	[1]
172	SETVKIGKVDCTQHY	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Disulfide bond; Redox-active center; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0016853; F:isomerase activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro. 

Interpro

 IPR005788; Disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.