CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018796
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poliovirus receptor-related protein 2 
Protein Synonyms/Alias
 Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin-2; CD112 
Gene Name
 PVRL2 
Gene Synonyms/Alias
 HVEB; PRR2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
407LEGPPSYKPPTPKAKubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Probable cell adhesion protein. 
Sequence Annotation
 DOMAIN 32 156 Ig-like V-type.
 DOMAIN 162 256 Ig-like C2-type 1.
 DOMAIN 261 345 Ig-like C2-type 2.
 MOD_RES 433 433 Phosphoserine.
 CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
 CARBOHYD 324 324 N-linked (GlcNAc...) (Potential).
 DISULFID 54 140 By similarity.
 DISULFID 183 238 By similarity.
 DISULFID 283 329 By similarity.  
Keyword
 3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Host cell receptor for virus entry; Host-virus interaction; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 538 AA 
Protein Sequence
MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV ELPCHLLPPV 60
PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS ERLSFVSAKQ STGQDTEAEL 120
QDATLALHGL TVEDEGNYTC EFATFPKGSV RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV 180
ALCISKEGRP PARISWLSSL DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV 240
EHESFEEPAL IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS 300
GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP NTAGAGATGG 360
IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL EGPPSYKPPT PKAKLEAQEM 420
PSQLFTLGAS EHSPLKTPYF DAGASCTEQE MPRYHELPTL EERSGPLHPG ATSLGSPIPV 480
PPGPPAVEDV SLDLEDEEGE EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV 538 
Gene Ontology
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005915; C:zonula adherens; ISS:BHF-UCL.
 GO:0015026; F:coreceptor activity; TAS:ProtInc.
 GO:0001675; P:acrosome assembly; IEA:Compara.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0051856; P:adhesion to symbiont; IDA:BHF-UCL.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0032990; P:cell part morphogenesis; IEA:Compara.
 GO:0007010; P:cytoskeleton organization; IEA:Compara.
 GO:0051654; P:establishment of mitochondrion localization; IEA:Compara.
 GO:0009566; P:fertilization; IEA:Compara.
 GO:0043064; P:flagellum organization; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; IDA:BHF-UCL.
 GO:0002891; P:positive regulation of immunoglobulin mediated immune response; IMP:BHF-UCL.
 GO:0033005; P:positive regulation of mast cell activation; IMP:BHF-UCL.
 GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IMP:BHF-UCL.
 GO:0030382; P:sperm mitochondrion organization; IEA:Compara.
 GO:0007286; P:spermatid development; ISS:BHF-UCL.
 GO:0007289; P:spermatid nucleus differentiation; IEA:Compara.
 GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IMP:BHF-UCL.
 GO:0060370; P:susceptibility to T cell mediated cytotoxicity; IDA:BHF-UCL.
 GO:0019064; P:viral entry into host cell via membrane fusion with the plasma membrane; IDA:BHF-UCL.
 GO:0046814; P:virion attachment, binding of host cell surface coreceptor; IDA:BHF-UCL. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 
Pfam
 PF08205; C2-set_2
 PF07686; V-set 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS