| Tag | Content |
|---|
| CPLM ID | CPLM-014495 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Complement component receptor 1-like protein |
Protein Synonyms/Alias | Antigen 5I2; Complement regulatory protein Crry |
Gene Name | Cr1l |
Gene Synonyms/Alias | Crry |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 74 | ECRPGYIKRQFSITC | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T- cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance. |
Sequence Annotation | DOMAIN 36 96 Sushi 1.
DOMAIN 97 158 Sushi 2.
DOMAIN 159 229 Sushi 3.
DOMAIN 231 290 Sushi 4.
DOMAIN 292 354 Sushi 5.
DOMAIN 355 415 Sushi 6.
DOMAIN 417 477 Sushi 7.
MOD_RES 537 537 Phosphoserine (By similarity).
MOD_RES 554 554 Phosphoserine (By similarity).
CARBOHYD 53 53 O-linked (GalNAc...) (Potential).
CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
DISULFID 38 81
DISULFID 68 94
DISULFID 99 140
DISULFID 126 156
DISULFID 161 210
DISULFID 190 227
DISULFID 233 275
DISULFID 261 288
DISULFID 294 336 By similarity.
DISULFID 322 352 By similarity.
DISULFID 357 400 By similarity.
DISULFID 386 413 By similarity.
DISULFID 419 462 By similarity.
DISULFID 448 475 By similarity. |
Keyword | 3D-structure; Alternative splicing; Complement pathway; Complete proteome; Developmental protein; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunity; Innate immunity; Membrane; Phosphoprotein; Pregnancy; Receptor; Reference proteome; Repeat; Signal; Sushi; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 559 AA |
Protein Sequence | MEASSPLDPV GRLVAFCRGG VHLAVLLLFL SPSTLGQCPA PPLFPYAKPI NPTDESTFPV 60
GTSLKYECRP GYIKRQFSIT CEVNSVWTSP QDVCIRKQCE TPLDPQNGIV HVNTDIRFGS 120
SITYTCNEGY RLIGSSSAMC IISDQSVAWD AEAPICESIP CEIPPSIPNG DFFSPNREDF 180
HYGMVVTYQC NTDARGKKLF NLVGEPSIHC TSIDGQVGVW SGPPPQCIEL NKCTPPHVEN 240
AVIVSKNKSL FSLRDMVEFR CQDGFMMKGD SSVYCRSLNR WEPQLPSCFK VKSCGAFLGE 300
LPNGHVFVPQ NLQLGAKVTF VCNTGYQLKG NSSSHCVLDG VESIWNSSVP VCEQVICKLP 360
QDMSGFQKGL QMKKDYYYGD NVALECEDGY TLEGSSQSQC QSDASWDPPL PKCVSQVICK 420
LPQDMSGFQK GLQMKKDYYY GDNVALECED GYTLEGSSQS QCQSDASWDP PLPKCVSRSN 480
SGLIAGIFIG IIVLILFIIF SYWMIMKFKK RNSTNEKCKE VGIYLNSKED SCVQPQSLLT 540
SQENNSTSSP ARNSLTQEV 559 |
Gene Ontology | GO:0009897; C:external side of plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0007565; P:female pregnancy; IEA:UniProtKB-KW. GO:0001701; P:in utero embryonic development; IEA:Compara. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0045916; P:negative regulation of complement activation; IMP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |