CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001891
UniProt Accession
Genbank Protein ID
 X02341 
Genbank Nucleotide ID
Protein Name
 VIP peptides 
Protein Synonyms/Alias
 Intestinal peptide PHV-42; Intestinal peptide PHI-27; Peptide histidine isoleucinamide 27; Vasoactive intestinal peptide; VIP; Vasoactive intestinal polypeptide 
Gene Name
 Vip 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
101LGQISAKKYLESLIGacetylation[1]
109YLESLIGKRISSSISacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. 
Sequence Annotation
 MOD_RES 107 107 Isoleucine amide.
 MOD_RES 152 152 Asparagine amide.
 CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
 CARBOHYD 133 133 N-linked (GlcNAc...) (Potential).  
Keyword
 Amidation; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Glycoprotein; Hormone; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 170 AA 
Protein Sequence
MESRSKPQFL AILTLFSVLF SQSLAWPLYG PPSSVRLDDR LQFEGAGDPD QVSLKADSDI 60
LQNALAENDT PYYDVSRNAR HADGVFTSDY SRLLGQISAK KYLESLIGKR ISSSISEDPV 120
PVKRHSDAVF TDNYTRLRKQ MAVKKYLNSI LNGKRSSEGD SPDFLEELEK 170 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005179; F:hormone activity; IDA:BHF-UCL.
 GO:0007611; P:learning or memory; IDA:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
 GO:0043267; P:negative regulation of potassium ion transport; IDA:RGD.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0010579; P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:RGD.
 GO:0060406; P:positive regulation of penile erection; IDA:RGD.
 GO:0045732; P:positive regulation of protein catabolic process; IDA:BHF-UCL.
 GO:0045909; P:positive regulation of vasodilation; IDA:RGD.
 GO:0032880; P:regulation of protein localization; IDA:BHF-UCL.
 GO:0051930; P:regulation of sensory perception of pain; IDA:RGD.
 GO:0009966; P:regulation of signal transduction; IEA:Compara. 
Interpro
 IPR000532; Glucagon_GIP_secretin_VIP.
 IPR015523; VIP. 
Pfam
 PF00123; Hormone_2 
SMART
 SM00070; GLUCA 
PROSITE
 PS00260; GLUCAGON 
PRINTS