UniProt Accession

 RT109_YEAST; Q07794; D6VY01 

Genbank Protein ID

 X91488; Z73107; BK006945 

Genbank Nucleotide ID

 CAA62768.1; CAA97445.1; DAA09317.1 

Protein Name

 Histone acetyltransferase RTT109 

Protein Synonyms/Alias

 Regulator of Ty1 transposition protein 109 

Gene Name

 RTT109 

Gene Synonyms/Alias

 KIM2; REM50; YLL002W; L1377 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
260	RSYLRGMKYPLWQVG	acetylation	[1]
290	PLFPDDPKARFIHQL	acetylation	[1, 2, 3]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.
 Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Cole PA, Marmorstein R.
 Nat Struct Mol Biol. 2008 Jul;15(7):738-45. [PMID: 18568037]
 [3] Autoacetylation of the histone acetyltransferase Rtt109.
 Albaugh BN, Arnold KM, Lee S, Denu JM.
 J Biol Chem. 2011 Jul 15;286(28):24694-701. [PMID: 21606491] 

Functional Description

 Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. H3K56 acetylation weakens of the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly. Involved in regulation of Ty1 transposition. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Transcription; Transcription regulation; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 436 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:SGD.
 GO:0010484; F:H3 histone acetyltransferase activity; IDA:SGD.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:SGD.
 GO:0010526; P:negative regulation of transposition, RNA-mediated; IMP:SGD.
 GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013178; Histone_H3-K56_AcTrfase_RTT109.
 IPR016849; Histone_H3-K56_AcTrfase_yeast. 

Pfam

 PF08214; KAT11 

SMART

  

PROSITE

  

PRINTS