UniProt Accession

 CD99_HUMAN; P14209; A6NIW1; O00518; Q6ICV7 

Genbank Protein ID

 X16996; U82164; CR450286; AC006209; CH471074; CH471074; BC002584; BC003147; BC010109; BC021620; BC024310; BQ948496; M16279; J03841 

Genbank Nucleotide ID

 CAA34863.1; AAB58501.1; CAG29282.1; EAW98697.1; EAW98698.1; AAH02584.1; AAH03147.1; AAH10109.1; AAH21620.1; AAH24310.1; AAA02999.1; AAA59848.1 

Protein Name

 CD99 antigen 

Protein Synonyms/Alias

 12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; CD99 

Gene Name

 CD99 

Gene Synonyms/Alias

 MIC2; MIC2X; MIC2Y 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
156	QKKKLCFKENAEQGE	ubiquitination	[1, 2, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell adhesion; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 185 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 

Interpro

 IPR022078; CD99L2. 

Pfam

 PF12301; CD99L2 

SMART

  

PROSITE

  

PRINTS