UniProt Accession

 ANLN_MOUSE; Q8K298; Q8BL79; Q8BLB3; Q8K2N0; Q9CUY0 

Genbank Protein ID

 BC030489; BC032164; AK013624; AK045703; AK046102 

Genbank Nucleotide ID

 AAH30489.1; AAH32164.1; BAB28931.3; BAC32464.1; BAC32605.1 

Protein Name

 Actin-binding protein anillin 

Protein Synonyms/Alias

  

Gene Name

 Anln 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
366	TPGGRGIKPFLERFG	acetylation	[1]
1116	WQPDACYKPVGKP**	acetylation	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression (By similarity). 

Sequence Annotation

 DOMAIN 980 1104 PH.
 REGION 1 228 Nuclear localization (By similarity).
 REGION 1 154 Interaction with CD2AP (By similarity).
 REGION 1 45 Required for ubiquitination (By
 REGION 229 671 Interaction with F-actin (By similarity).
 REGION 725 1121 Localization to the cleavage furrow (By
 MOD_RES 73 73 Phosphoserine (By similarity).
 MOD_RES 180 180 Phosphoserine (By similarity).
 MOD_RES 192 192 Phosphothreonine (By similarity).
 MOD_RES 316 316 Phosphothreonine (By similarity).
 MOD_RES 318 318 Phosphoserine (By similarity).
 MOD_RES 359 359 Phosphothreonine (By similarity).
 MOD_RES 366 366 N6-acetyllysine (By similarity).
 MOD_RES 392 392 Phosphothreonine (By similarity).
 MOD_RES 396 396 Phosphothreonine (By similarity).
 MOD_RES 444 444 Phosphoserine (By similarity).
 MOD_RES 510 510 Phosphothreonine.
 MOD_RES 513 513 Phosphoserine (By similarity).
 MOD_RES 548 548 Phosphoserine (By similarity).
 MOD_RES 556 556 Phosphoserine (By similarity).
 MOD_RES 637 637 Phosphoserine.
 MOD_RES 653 653 Phosphoserine (By similarity).
 MOD_RES 656 656 Phosphoserine (By similarity).
 MOD_RES 659 659 Phosphoserine (By similarity).
 MOD_RES 924 924 Phosphoserine (By similarity).  

Keyword

 Acetylation; Actin-binding; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1121 AA 

Protein Sequence

Gene Ontology

 GO:0005826; C:actomyosin contractile ring; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0000910; P:cytokinesis; IEA:Compara.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW. 

Interpro

 IPR012966; DUF1709.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

 PF08174; Anillin
 PF00169; PH 

SMART

 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN 

PRINTS