CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016779
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tsukushin 
Protein Synonyms/Alias
 Tsukushi; Leucine-rich repeat-containing protein 54 
Gene Name
 Tsku 
Gene Synonyms/Alias
 Lrrc54; Tsk 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
267LDLSGNPKLKWAGAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 18 59 LRRNT.
 REPEAT 60 81 LRR 1.
 REPEAT 86 107 LRR 2.
 REPEAT 110 131 LRR 3.
 REPEAT 133 154 LRR 4.
 REPEAT 160 180 LRR 5.
 REPEAT 186 207 LRR 6.
 REPEAT 208 228 LRR 7.
 REPEAT 231 253 LRR 8.
 REPEAT 256 277 LRR 9.
 REPEAT 281 302 LRR 10.
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MLCSLFLLLL AVGRVQTTRP CFPGCQCEEE TFGLFDSFSL IRVDCSSLGP HIVPVPIPLD 60
TAHLDLSSNR LETVNESVLA GPGYTTLAGL DLSYNLLTSI MPSAFSRLRY LESLDLSHNG 120
LAALPAEIFT SSPLSDINLS HNRLREVSIS AFTTHSQGRA LHVDLSHNLI HRLLPHPARA 180
SLPAPTIQSL NLSWNRFRAV PDLRDLPLRY LSLDGNPLAT INPDAFMGLA GLTHLSLASL 240
QGILHLPPHG FRELPGLQVL DLSGNPKLKW AGAEVFSGLG LLQELDLSGS SLVPLPEMLL 300
HHLPALQSVS VGQDVQCRRL VREGAYHRQP GSSPKVVLHC GDTQESAARG PDIL 354 
Gene Ontology
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0021960; P:anterior commissure morphogenesis; IMP:MGI.
 GO:0061073; P:ciliary body morphogenesis; IMP:MGI.
 GO:0021540; P:corpus callosum morphogenesis; IMP:MGI.
 GO:0021670; P:lateral ventricle development; IMP:MGI.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IDA:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 
Pfam
 PF00560; LRR_1 
SMART
 SM00369; LRR_TYP
 SM00013; LRRNT 
PROSITE
 PS51450; LRR 
PRINTS