CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021934
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 40 member 1 
Protein Synonyms/Alias
 Ferroportin-1; Iron-regulated transporter 1 
Gene Name
 SLC40A1 
Gene Synonyms/Alias
 FPN1; IREG1; SLC11A3; MSTP079 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
247KEEETELKQLNLHKDubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). 
Sequence Annotation
 CARBOHYD 174 174 N-linked (GlcNAc...) (Potential).
 CARBOHYD 434 434 N-linked (GlcNAc...) (Potential).
 CARBOHYD 567 567 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Ion transport; Iron; Iron transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 571 AA 
Protein Sequence
MTRAGDHNRQ RGCCGSLADY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL 60
TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKHEL 120
LTMYHGWVLT SCYILIITIA NIANLASTAT AITIQRDWIV VVAGEDRSKL ANMNATIRRI 180
DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY VLLWKVYQKT PALAVKAGLK 240
EEETELKQLN LHKDTEPKPL EGTHLMGVKD SNIHELEHEQ EPTCASQMAE PFRTFRDGWV 300
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF 360
TWLRRKCGLV RTGLISGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFIQGESITP 420
TKIPEITTEI YMSNGSNSAN IVPETSPESV PIISVSLLFA GVIAARIGLW SFDLTVTQLL 480
QENVIESERG IINGVQNSMN YLLDLLHFIM VILAPNPEAF GLLVLISVSF VAMGHIMYFR 540
FAQNTLGNKL FACGPDAKEV RKENQANTSV V 571 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005887; C:integral to plasma membrane; IC:BHF-UCL.
 GO:0005771; C:multivesicular body; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005381; F:iron ion transmembrane transporter activity; IMP:BHF-UCL.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0006879; P:cellular iron ion homeostasis; IMP:BHF-UCL.
 GO:0003158; P:endothelium development; IEA:Compara.
 GO:0002260; P:lymphocyte homeostasis; IEA:Compara.
 GO:0060586; P:multicellular organismal iron ion homeostasis; IEA:Compara.
 GO:0060345; P:spleen trabecula formation; IEA:Compara. 
Interpro
 IPR009716; Ferroportin-1.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF06963; FPN1 
SMART
  
PROSITE
  
PRINTS