CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001015
UniProt Accession
Genbank Protein ID
 Y15909; Y15908; AL139809; AL031053; AL161624; AL391821; AL592157; AL606530; AL669876; Z86061; AL161624; AL031053; AL139809; AL391821; AL592157; AL606530; AL669876; Z86061; AL592157; AL031053; AL139809; AL161624; AL391821; AL606530; AL669876; Z86061; AL606530; AL031053; AL139809; AL161624; AL391821; AL592157; AL669876; Z86061; Z86061; AL031053; AL139809; AL161624; AL391821; AL592157; AL606530; AL669876; AL031053; AL139809; AL161624; AL391821; AL592157; AL606530; AL669876; Z86061; AL669876; AL031053; AL139809; AL161624; AL391821; AL592157; AL606530; Z86061; AL669876; AL031053; AL139809; AL161624; AL592157; AL606530; Z86061; AL391821; AL031053; AL139809; AL161624; AL592157; AL606530; AL669876; Z86061; AL592157; AL031053; AL139809; AL161624; AL606530; AL669876; Z86061; AL606530; AL031053; AL139809; AL161624; AL592157; AL669876; Z86061; Z86061; AL031053; AL139809; AL161624; AL592157; AL606530; AL669876; AL161624; AL031053; AL139809; AL592157; AL606530; AL669876; Z86061; AL031053; AL139809 
Genbank Nucleotide ID
 CAA75870.1; CAA75869.1; CAI39928.1; CAI39928.1; CAI39928.1; CAI39928.1; CAI39928.1; CAI39928.1; CAI39928.1; CAI39928.1; CAI40915.1; CAI40915.1; CAI40915.1; CAI40915.1; CAI40915.1; CAI40915.1; CAI40915.1; CAI40915.1; CAI40544.1; CAI40544.1; CAI40544.1; CAI40544.1; CAI40544.1; CAI40544.1; CAI40544.1; CAI40544.1; CAI39841.1; CAI39841.1; CAI39841.1; CAI39841.1; CAI39841.1; CAI39841.1; CAI39841.1; CAI39841.1; CAI42257.1; CAI42257.1; CAI42257.1; CAI42257.1; CAI42257.1; CAI42257.1; CAI42257.1; CAI42257.1; CAI42515.1; CAI42515.1; CAI42515.1; CAI42515.1; CAI42515.1; CAI42515.1; CAI42515.1; CAI42515.1; CAH71113.1; CAH71113.1; CAH71113.1; CAH71113.1; CAH71113.1; CAH71113.1; CAH71113.1; CAH71113.1; CAH71114.1; CAH71114.1; CAH71114.1; CAH71114.1; CAH71114.1; CAH71114.1; CAH71114.1; CAH71361.1; CAH71361.1; CAH71361.1; CAH71361.1; CAH71361.1; CAH71361.1; CAH71361.1; CAH71361.1; CAI40545.1; CAI40545.1; CAI40545.1; CAI40545.1; CAI40545.1; CAI40545.1; CAI40545.1; CAI39842.1; CAI39842.1; CAI39842.1; CAI39842.1; CAI39842.1; CAI39842.1; CAI39842.1; CAI42258.1; CAI42258.1; CAI42258.1; CAI42258.1; CAI42258.1; CAI42258.1; CAI42258.1; CAI40916.1; CAI40916.1; CAI40916.1; CAI40916.1; CAI40916.1; CAI40916.1; CAI40916.1; CAB39108.2; CAD13477.2 
Protein Name
 Protein diaphanous homolog 2 
Protein Synonyms/Alias
 Diaphanous-related formin-2; DRF2 
Gene Name
 DIAPH2 
Gene Synonyms/Alias
 DIA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123DMNLNEEKKAPLRNKacetylation[1]
124MNLNEEKKAPLRNKDacetylation[1]
130KKAPLRNKDFTTKREacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. 
Sequence Annotation
 DOMAIN 98 464 GBD/FH3.
 DOMAIN 549 623 FH1.
 DOMAIN 628 1028 FH2.
 DOMAIN 1051 1081 DAD.
 MOD_RES 1 1 N-acetylmethionine.  
Keyword
 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Endosome; Oogenesis; Polymorphism; Premature ovarian failure; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1101 AA 
Protein Sequence
MEQPGAAASG AGGGSEEPGG GRSNKRSAGN RAANEEETKN KPKLNIQIKT LADDVRDRIT 60
SFRKSTVKKE KPLIQHPIDS QVAMSEFPAA QPLYDERSLN LSEKEVLDLF EKMMEDMNLN 120
EEKKAPLRNK DFTTKREMVV QYISATAKSG GLKNSKHECT LSSQEYVHEL RSGISDEKLL 180
NCLESLRVSL TSNPVSWVNN FGHEGLGLLL DELEKLLDKK QQENIDKKNQ YKLIQCLKAF 240
MNNKFGLQRI LGDERSLLLL ARAIDPKQPN MMTEIVKILS AICIVGEENI LDKLLGAITT 300
AAERNNRERF SPIVEGLENQ EALQLQVACM QFINALVTSP YELDFRIHLR NEFLRSGLKT 360
MLPDLKEKEN DELDIQLKVF DENKEDDLTE LSHRLNDIRA EMDDMNEVYH LLYNMLKDTA 420
AENYFLSILQ HFLLIRNDYY IRPQYYKIIE ECVSQIVLHC SGMDPDFKYR QRLDIDLTHL 480
IDSCVNKAKV EESEQKAAEF SKKFDEEFTA RQEAQAELQK RDEKIKELEA EIQQLRTQAQ 540
VLSSSSGIPG PPAAPPLPGV GPPPPPPAPP LPGGAPLPPP PPPLPGMMGI PPPPPPPLLF 600
GGPPPPPPLG GVPPPPGISL NLPYGMKQKK MYKPEVSMKR INWSKIEPTE LSENCFWLRV 660
KEDKFENPDL FAKLALNFAT QIKVQKNAEA LEEKKTGPTK KKVKELRILD PKTAQNLSIF 720
LGSYRMPYED IRNVILEVNE DMLSEALIQN LVKHLPEQKI LNELAELKNE YDDLCEPEQF 780
GVVMSSVKML QPRLSSILFK LTFEEHINNI KPSIIAVTLA CEELKKSESF NRLLELVLLV 840
GNYMNSGSRN AQSLGFKINF LCKIRDTKSA DQKTTLLHFI ADICEEKYRD ILKFPEELEH 900
VESASKVSAQ ILKSNLASME QQIVHLERDI KKFPQAENQH DKFVEKMTSF TKTAREQYEK 960
LSTMHNNMMK LYENLGEYFI FDSKTVSIEE FFGDLNNFRT LFLEAVRENN KRREMEEKTR 1020
RAKLAKEKAE QEKLERQKKK KQLIDINKEG DETGVMDNLL EALQSGAAFR DRRKRIPRNP 1080
DNRRVPLERS RSRHNGAISS K 1101 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0030041; P:actin filament polymerization; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0000910; P:cytokinesis; TAS:ProtInc.
 GO:0007292; P:female gamete generation; TAS:ProtInc.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0048477; P:oogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR003104; Actin-bd_FH2/DRF_autoreg.
 IPR016024; ARM-type_fold.
 IPR014767; Diaphanous_autoregulatory.
 IPR010465; Drf_DAD.
 IPR010472; Drf_FH3.
 IPR010473; Drf_GTPase-bd.
 IPR015425; FH2_actin-bd.
 IPR014768; GTPase-bd/formin_homology_3. 
Pfam
 PF06345; Drf_DAD
 PF06367; Drf_FH3
 PF06371; Drf_GBD
 PF02181; FH2 
SMART
 SM00498; FH2 
PROSITE
 PS51231; DAD
 PS51444; FH2
 PS51232; GBD_FH3 
PRINTS