| Tag | Content |
|---|
| CPLM ID | CPLM-006643 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UDP-glucuronosyltransferase 2B15 |
Protein Synonyms/Alias | UDPGT 2B15; UDP-glucuronosyltransferase 2B36; UDPGT 2B36 |
Gene Name | Ugt2b15 |
Gene Synonyms/Alias | Ugt2b12; Ugt2b36; Ugt2b4 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 67 | AFVFLDPKETSDLKF | acetylation | [1] | | 140 | SNKQFMTKLQESKFD | acetylation | [1] | | 232 | FQTFREKKWDPFYSK | acetylation | [1] | | 356 | GPNTRLYKWLPQNDL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Catalyzes the transfer of glucuronic acid from UDP-glucuronic acid to various aglycone molecules. Catalyzes the glucuronidation of monoterpenoid alcohols, such as (-)- borneol, (+)-menthol, and (-)- nopol. In addition, a number of simple phenolic compounds, such as hydroxybiphenyls, 7- hydroxylated coumarins, p-nitrophenol, and food-derived substances (e.g. naringenin and eugenol), and 4-methylumbelliferone are also substrates. |
Sequence Annotation | CARBOHYD 316 316 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Microsome; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 530 AA |
Protein Sequence | MSGKWISALL LLQISFCFKS GNCGKVLVWP MEYSHWMNIK IILEELVQKG HEVTVLRPSA 60
FVFLDPKETS DLKFVTFPTS FSSHDLENFF TRFVNVWTYE LPRDTCLSYF LYLQDTIDEY 120
SDYCLTVCKE AVSNKQFMTK LQESKFDVVF SDAIGPCGEL IAELLQIPFL YSLRFSPGYT 180
IEQYIGGVLF PPSYVPMIFS GLAGQMTFIE RVHNMICMLY FDFWFQTFRE KKWDPFYSKT 240
LGRPTTLAEI MGKAEMWLIR SYWDLEFPHP ISPNVDYIGG LHCKPAKPLP KDIEDFVQSS 300
GEHGVVVFSL GSMVRNMTEE KANIIAWALA QIPQKVLWRF DGKKPPTLGP NTRLYKWLPQ 360
NDLLGHPKTK AFVTHGGANG IYEAIHHGIP MIGIPLFAEQ HDNIAHMVAK GAAVEVNFRT 420
MSKSDLLNAL EEVIDNPFYK KNAMWLSTIH HDQPTKPLDR AVFWIEFVMR HKGAKHLRSL 480
GHNLPWYQYH SLDVIGFLLS CVAVTVVLAL KCFLFVYRFF VKKEKKTKNE 530 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD. GO:0015020; F:glucuronosyltransferase activity; IDA:RGD. GO:0019439; P:aromatic compound catabolic process; IDA:RGD. GO:0042493; P:response to drug; IEP:RGD. |
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