UniProt Accession

 FAAA_MOUSE; P35505; Q3TY87; Q9QW65 

Genbank Protein ID

 M84145; Z11774; AK143759; AK158808; BC010767 

Genbank Nucleotide ID

 AAA37591.1; CAA77819.1; BAE25527.1; BAE34676.1; AAH10767.1 

Protein Name

 Fumarylacetoacetase 

Protein Synonyms/Alias

 FAA; Beta-diketonase; Fumarylacetoacetate hydrolase 

Gene Name

 Fah 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
100	QARLRDDKELRQRAF	acetylation	[1]
100	QARLRDDKELRQRAF	ubiquitination	[2]
144	VGIMFRGKENALLPN	ubiquitination	[2]
371	ELSWKGTKAIDVEQG	ubiquitination	[2]
411	GFGQCAGKVLPALSP	acetylation	[3]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

 ACT_SITE 133 133 Proton acceptor (Probable).
 METAL 126 126 Calcium.
 METAL 199 199 Calcium.
 METAL 201 201 Calcium.
 METAL 233 233 Calcium.
 METAL 233 233 Magnesium.
 METAL 253 253 Magnesium.
 METAL 257 257 Magnesium.
 BINDING 128 128 Substrate.
 BINDING 142 142 Substrate.
 BINDING 240 240 Substrate.
 BINDING 244 244 Substrate.
 BINDING 350 350 Substrate.
 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 3D-structure; Acetylation; Calcium; Complete proteome; Hydrolase; Magnesium; Metal-binding; Phenylalanine catabolism; Reference proteome; Tyrosine catabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 419 AA 

Protein Sequence

Gene Ontology

 GO:0004334; F:fumarylacetoacetase activity; IMP:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006527; P:arginine catabolic process; IMP:MGI.
 GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR005959; Fumarylacetoacetase.
 IPR002529; Fumarylacetoacetase_C.
 IPR011234; Fumarylacetoacetase_C-rel.
 IPR015377; Fumarylacetoacetase_N. 

Pfam

 PF09298; DUF1969
 PF01557; FAA_hydrolase 

SMART

  

PROSITE

  

PRINTS