CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037478
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Filamin-A 
Protein Synonyms/Alias
  
Gene Name
 FLNA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15QPTITDNKDGTVTVRacetylation[1]
15QPTITDNKDGTVTVRubiquitination[2, 3, 4]
97SMRMSHLKVGSAADIubiquitination[2, 4]
133REEPCLLKRLRNGHVubiquitination[2]
266PGSPFSVKVTGEGRVacetylation[1]
348GTHTVSVKYKGQHVPacetylation[1]
348GTHTVSVKYKGQHVPubiquitination[2]
350HTVSVKYKGQHVPGSubiquitination[2]
373LGEGGAHKVRAGGPGubiquitination[2]
550HIPGSPFKIRVGEPGubiquitination[2]
606IDGPSKVKMDCQECPubiquitination[5, 6, 7]
673VFVDSLTKATCAPQHubiquitination[5]
702AKGLGLSKAYVGQKSacetylation[1, 8]
717SFTVDCSKAGNNMLLubiquitination[6]
740PCEEILVKHVGSRLYacetylation[1, 7, 8]
754YSVSYLLKDKGEYTLacetylation[8]
754YSVSYLLKDKGEYTLubiquitination[2]
756VSYLLKDKGEYTLVVacetylation[7]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 780 AA 
Protein Sequence
MPSGKVAQPT ITDNKDGTVT VRYAPSEAGL HEMDIRYDNM HIPGSPLQFY VDYVNCGHVT 60
AYGPGLTHGV VNKPATFTVN TKDAGEGDDS MRMSHLKVGS AADIPINISE TDLSLLTATV 120
VPPSGREEPC LLKRLRNGHV GISFVPKETG EHLVHVKKNG QHVASSPIPV VISQSEIGDA 180
SRVRVSGQGL HEGHTFEPAE FIIDTRDAGY GGLSLSIEGP SKVDINTEDL EDGTCRVTYC 240
PTEPGNYIIN IKFADQHVPG SPFSVKVTGE GRVKESITRR RRAPSVANVG SHCDLSLKIP 300
EISIQDMTAQ VTSPSGKTHE AEIVEGENHT YCIRFVPAEM GTHTVSVKYK GQHVPGSPFQ 360
FTVGPLGEGG AHKVRAGGPG LERAEAGVPA EFSIWTREAG AGGLAIAVEG PSKAEISFED 420
RKDGSCGVAY VVQEPGDYEV SVKFNEEHIP DSPFVVPVAS PSGDARRLTV SSLQESGLKV 480
NQPASFAVSL NGAKGAIDAK VHSPSGALEE CYVTEIDQDK YAVRFIPREN GVYLIDVKFN 540
GTHIPGSPFK IRVGEPGHGG DPGLVSAYGA GLEGGVTGNP AEFVVNTSNA GAGALSVTID 600
GPSKVKMDCQ ECPEGYRVTY TPMAPGSYLI SIKYGGPYHI GGSPFKAKVT GPRLVSNHSL 660
HETSSVFVDS LTKATCAPQH GAPGPGPADA SKVVAKGLGL SKAYVGQKSS FTVDCSKAGN 720
NMLLVGVHGP RTPCEEILVK HVGSRLYSVS YLLKDKGEYT LVVKWGDEHI PGSPYRVVVP 780 
Gene Ontology
  
Interpro
 IPR001298; Filamin.
 IPR017868; Filamin/ABP280_repeat-like.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set. 
Pfam
 PF00630; Filamin 
SMART
 SM00557; IG_FLMN 
PROSITE
 PS50194; FILAMIN_REPEAT 
PRINTS