UniProt Accession

 PHOS_HUMAN; P20941; Q14816; Q9UP22 

Genbank Protein ID

 M33478; M38059; M60720; M38058; AF076464; AL596220; AL663036; CH471067 

Genbank Nucleotide ID

 AAA35486.1; AAA36210.1; AAA36210.1; AAA36210.1; AAD43142.1; CAI13122.1; EAW91212.1 

Protein Name

 Phosducin 

Protein Synonyms/Alias

 PHD; 33 kDa phototransducing protein; Protein MEKA 

Gene Name

 PDC 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	INDWRKFKLESQDSD	sumoylation	[1]

Reference

 [1] SUMO-1 controls the protein stability and the biological function of phosducin.
 Klenk C, Humrich J, Quitterer U, Lohse MJ.
 J Biol Chem. 2006 Mar 31;281(13):8357-64. [PMID: 16421094] 

Functional Description

 May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. 

Sequence Annotation

 MOD_RES 73 73 Phosphoserine; by PKA (By similarity).  

Keyword

 Alternative splicing; Cell projection; Cilium; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Sensory transduction; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
 GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
 GO:0004859; F:phospholipase inhibitor activity; TAS:ProtInc.
 GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0007602; P:phototransduction; TAS:ProtInc.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 

Interpro

 IPR001200; Phosducin.
 IPR023196; Phosducin_N_dom.
 IPR024253; Phosducin_thioredoxin-like_dom.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF02114; Phosducin 

SMART

  

PROSITE

  

PRINTS

 PR00677; PHOSDUCIN.