CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017144
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Proline-, glutamic acid- and leucine-rich protein 1 
Protein Synonyms/Alias
 Modulator of non-genomic activity of estrogen receptor; Transcription factor HMX3 
Gene Name
 PELP1 
Gene Synonyms/Alias
 HMX3; MNAR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
103NARLSSIKTRFEGLCubiquitination[1]
216ACGSLKGKLASFFLSubiquitination[1]
354RTLSVSSKNISLHGDubiquitination[1]
826ASPPVPAKEEPEELPsumoylation[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.
 Finkbeiner E, Haindl M, Muller S.
 EMBO J. 2011 Mar 16;30(6):1067-78. [PMID: 21326211]
 [3] SUMO routes ribosome maturation.
 Finkbeiner E, Haindl M, Raman N, Muller S.
 Nucleus. 2011 Nov-Dec;2(6):527-32. [PMID: 22064470] 
Functional Description
 Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. 
Sequence Annotation
 MOTIF 33 37 LXXLL motif 1.
 MOTIF 69 73 LXXLL motif 2.
 MOTIF 111 115 LXXLL motif 3.
 MOTIF 155 159 LXXLL motif 4.
 MOTIF 177 181 LXXLL motif 5.
 MOTIF 264 268 LXXLL motif 6.
 MOTIF 271 275 LXXLL motif 7.
 MOTIF 364 368 LXXLL motif 8.
 MOTIF 459 463 LXXLL motif 9.
 MOTIF 579 583 LXXLL motif 10.
 MOTIF 584 588 LXXLL motif 11.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 13 13 Phosphoserine (By similarity).
 MOD_RES 477 477 Phosphoserine.
 MOD_RES 481 481 Phosphoserine.
 MOD_RES 488 488 Phosphothreonine.
 MOD_RES 745 745 Phosphothreonine.
 MOD_RES 1033 1033 Phosphoserine.
 MOD_RES 1043 1043 Phosphoserine.  
Keyword
 Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1130 AA 
Protein Sequence
MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG SAVAPVHPPN 60
RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS SIKTRFEGLC LLSLLVGESP 120
TELFQQHCVS WLRSIQQVLQ TQDPPATMEL AVAVLRDLLR YAAQLPALFR DISMNHLPGL 180
LTSLLGLRPE CEQSALEGMK ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY 240
SRLPSLGAGF SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS 300
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS VSSKNISLHG 360
DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR LLPQVLNSWS IGRDSLSPGQ 420
ERPYSTVRTK VYAILELWVQ VCGASAGMLQ GGASGEALLT HLLSDISPPA DALKLRSPRG 480
SPDGSLQTGK PSAPKKLKLD VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI 540
KEETHRRLHD LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC 600
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP VPPPEAPSPF 660
RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP GPPTTANHLG LSVPGLVSVP 720
PRLLPGPENH RAGSNEDPIL APSGTPPPTI PPDETFGGRV PRPAFVHYDK EEASDVEISL 780
ESDSDDSVVI VPEGLPPLPP PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP 840
PPPPPPPPVP GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE 900
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED EEEEEELEEV 960
EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE PEPGLLLEVE EPGTEEERGA 1020
DTAPTLAPEA LPSQGEVERE GESPAAGPPP QELVEEEPSA PPTLLEEETE DGSDKVQPPP 1080
ETPAEEEMET ETEAEALQEK EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS 1130 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0071339; C:MLL1 complex; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR012980; Uncharacterised_NUC202. 
Pfam
 PF08166; NUC202 
SMART
  
PROSITE
  
PRINTS