CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027761
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 B-cell specific latent nuclear protein 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) 
NCBI Taxa ID
 37296 
Lysine Modification
Position
Peptide
Type
References
57LQFFIDFKRECLSKGsumoylation[1]
Reference
 [1] Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2.
 Marcos-Villar L, Campagna M, Lopitz-Otsoa F, Gallego P, González-Santamaría J, González D, Rodriguez MS, Rivas C.
 J Gen Virol. 2011 Jan;92(Pt 1):188-94. [PMID: 20881090] 
Functional Description
  
Sequence Annotation
  
Keyword
 Nucleus. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 567 AA 
Protein Sequence
MAGRRLTWIS EFIVGALDSD KYPLVKWLDR STGTFLAPAA RNDVIPLDSL QFFIDFKREC 60
LSKGLHPRDL LGSPITAFGK ICTTSRRLRR LPGEEYEVVQ GINCRRWRLL CAEVKECWWC 120
VHARTHLHSG SSLWEILYQH SVRLEKHRRR PRRPFVGENS DSSEEDHPAF CDVPVTQTGA 180
ESEDSGDEGP STRHSASGVQ PVDDANADSP GSGDEGPSTR HSDSQPPPAD ETTVHTDNVE 240
DDLTLLDKES ACALMYHVGQ EMDMLMRAMC DEDLFDLLGI PEDVIATSQP GGDTDASGVV 300
TEGSIAASAV GAGVEDVYLA GALEAQNVAG EYVLEISDEE VDDGAGLPPA SRRRPVVGEF 360
LWDDGPRRHE RPTTRRIRHR KLRSAYYRVA RPPVMITDRL GVEVFYFGRP AMSLEVERKV 420
FILCSQNPLA DISHSCLHSR KGLRVLLPKP DDNNTGPGDV NLLAAVLRSF ASGLVIVSLR 480
SGIYVKNLCK STVLYHGNNP PKKFGVICGL SSRAVLDVFN VAQYRIQGHE HIKKTTVFIG 540
GDPTSAEQFD MVPLVIKLRL RSVTCDD 567 
Gene Ontology
 GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW.
 GO:0000975; F:regulatory region DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR001346; Interferon_reg_fact_DNA-bd_dom.
 IPR019471; Interferon_reg_factor-3.
 IPR017855; SMAD_dom-like.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF10401; IRF-3 
SMART
  
PROSITE
 PS51507; IRF_2 
PRINTS