CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005094
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chromosome partition protein MukB 
Protein Synonyms/Alias
 Structural maintenance of chromosome-related protein 
Gene Name
 mukB 
Gene Synonyms/Alias
 b0924; JW0907 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
115QVAGRDRKVDIKPFAacetylation[1]
119RDRKVDIKPFAIQGLacetylation[1]
154VLPLNELKDKLEAMEacetylation[1]
287ERRVHLDKALEFRREacetylation[1]
308QLAAEQYKHVDMAREacetylation[1]
349TALRQQEKIERYEADacetylation[1]
396ELEVDELKSQLADYQacetylation[1]
457KELEATEKMLSLEQKacetylation[1]
544RLLADFCKRQGKNFDacetylation[1]
548DFCKRQGKNFDIDELacetylation[1]
810TLSFDVQKTQRLHQAacetylation[1]
870RIQFEQAKEGVTALNacetylation[1]
940PEQFEQLKEDYAYSQacetylation[1]
988GNSDLNEKLRERLEQacetylation[1]
1025NQVLASLKSSYDTKKacetylation[1]
1152DLRSMSDKALGALRLacetylation[1]
1314TFSEALAKLYQRLNPacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. 
Sequence Annotation
 NP_BIND 34 41 ATP (Potential).
 REGION 645 804 Sufficient for ParC binding.
 REGION 666 783 Flexible hinge.  
Keyword
 3D-structure; ATP-binding; Cell cycle; Cell division; Chromosome partition; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; DNA condensation; DNA-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1486 AA 
Protein Sequence
MIERGKFRSL TLINWNGFFA RTFDLDELVT TLSGGNGAGK STTMAAFVTA LIPDLTLLHF 60
RNTTEAGATS GSRDKGLHGK LKAGVCYSML DTINSRHQRV VVGVRLQQVA GRDRKVDIKP 120
FAIQGLPMSV QPTQLVTETL NERQARVLPL NELKDKLEAM EGVQFKQFNS ITDYHSLMFD 180
LGIIARRLRS ASDRSKFYRL IEASLYGGIS SAITRSLRDY LLPENSGVRK AFQDMEAALR 240
ENRMTLEAIR VTQSDRDLFK HLISEATNYV AADYMRHANE RRVHLDKALE FRRELHTSRQ 300
QLAAEQYKHV DMARELAEHN GAEGDLEADY QAASDHLNLV QTALRQQEKI ERYEADLDEL 360
QIRLEEQNEV VAEAIERQQE NEARAEAAEL EVDELKSQLA DYQQALDVQQ TRAIQYNQAI 420
AALNRAKELC HLPDLTADCA AEWLETFQAK ELEATEKMLS LEQKMSMAQT AHSQFEQAYQ 480
LVVAINGPLA RNEAWDVARE LLREGVDQRH LAEQVQPLRM RLSELEQRLR EQQEAERLLA 540
DFCKRQGKNF DIDELEALHQ ELEARIASLS DSVSNAREER MALRQEQEQL QSRIQSLMQR 600
APVWLAAQNS LNQLSEQCGE EFTSSQDVTE YLQQLLERER EAIVERDEVG ARKNAVDEEI 660
ERLSQPGGSE DQRLNALAER FGGVLLSEIY DDVSLEDAPY FSALYGPSRH AIVVPDLSQV 720
TEHLEGLTDC PEDLYLIEGD PQSFDDSVFS VDELEKAVVV KIADRQWRYS RFPEVPLFGR 780
AARESRIESL HAEREVLSER FATLSFDVQK TQRLHQAFSR FIGSHLAVAF ESDPEAEIRQ 840
LNSRRVELER ALSNHENDNQ QQRIQFEQAK EGVTALNRIL PRLNLLADDS LADRVDEIRE 900
RLDEAQEAAR FVQQFGNQLA KLEPIVSVLQ SDPEQFEQLK EDYAYSQQMQ RDARQQAFAL 960
TEVVQRRAHF SYSDSAEMLS GNSDLNEKLR ERLEQAEAER TRAREALRGH AAQLSQYNQV 1020
LASLKSSYDT KKELLNDLQR ELQDIGVRAD SGAEERARIR RDELHAQLSN NRSRRNQLEK 1080
ALTFCEAEMD NLTRKLRKLE RDYFEMREQV VTAKAGWCAV MRMVKDNGVE RRLHRRELAY 1140
LSADDLRSMS DKALGALRLA VADNEHLRDV LRMSEDPKRP ERKIQFFVAV YQHLRERIRQ 1200
DIIRTDDPVE AIEQMEIELS RLTEELTSRE QKLAISSRSV ANIIRKTIQR EQNRIRMLNQ 1260
GLQNVSFGQV NSVRLNVNVR ETHAMLLDVL SEQHEQHQDL FNSNRLTFSE ALAKLYQRLN 1320
PQIDMGQRTP QTIGEELLDY RNYLEMEVEV NRGSDGWLRA ESGALSTGEA IGTGMSILVM 1380
VVQSWEDESR RLRGKDISPC RLLFLDEAAR LDARSIATLF ELCERLQMQL IIAAPENISP 1440
EKGTTYKLVR KVFQNTEHVH VVGLRGFAPQ LPETLPGTDE APSQAS 1486 
Gene Ontology
 GO:0000796; C:condensin complex; IDA:EcoCyc.
 GO:0005737; C:cytoplasm; IEA:HAMAP.
 GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IDA:EcoCyc.
 GO:0003677; F:DNA binding; IDA:EcoCyc.
 GO:0005525; F:GTP binding; IDA:EcoCyc.
 GO:0051301; P:cell division; IMP:EcoCyc.
 GO:0030261; P:chromosome condensation; IDA:EcoCyc.
 GO:0006260; P:DNA replication; IEA:HAMAP.
 GO:0007062; P:sister chromatid cohesion; IMP:EcoliWiki. 
Interpro
 IPR012090; MukB.
 IPR007406; MukB_N_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF04310; MukB 
SMART
  
PROSITE
  
PRINTS