UniProt Accession

 PPAC_MOUSE; Q9D358; O88739; O88740; Q9QWF5 

Genbank Protein ID

 Y17343; Y17344; Y17345; AK014603; AK018329; AK019186; AK082955; BC039744 

Genbank Nucleotide ID

 CAA76753.1; CAA76754.1; CAA76755.1; BAB29458.1; BAB31164.1; BAB31593.1; BAC38707.1; AAH39744.1 

Protein Name

 Low molecular weight phosphotyrosine protein phosphatase 

Protein Synonyms/Alias

 LMW-PTP; LMW-PTPase; Low molecular weight cytosolic acid phosphatase 

Gene Name

 Acp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
35	RKLVTDEKVSDNWRI	ubiquitination	[1]
66	RGQNCMRKHGIHMQH	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates (By similarity). 

Sequence Annotation

 ACT_SITE 13 13 Nucleophile (By similarity).
 ACT_SITE 19 19 By similarity.
 ACT_SITE 130 130 Proton donor (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 132 132 Phosphotyrosine (By similarity).
 MOD_RES 133 133 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 158 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003993; F:acid phosphatase activity; IDA:MGI.
 GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0007268; P:synaptic transmission; IEA:Compara. 

Interpro

 IPR023485; Ptyr_pPase_SF.
 IPR002115; Tyr_Pase_low_mol_wt_mml.
 IPR000106; Tyr_phospatase/Ars_reductase.
 IPR017867; Tyr_phospatase_low_mol_wt. 

Pfam

 PF01451; LMWPc 

SMART

 SM00226; LMWPc 

PROSITE

  

PRINTS

 PR00719; LMWPTPASE.
 PR00720; MAMMALPTPASE.