CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein kinase PLK4 
Protein Synonyms/Alias
  
Gene Name
 PLK4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
478QGHPDLQKDTSKNAWubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 909 AA 
Protein Sequence
MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60
VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY LKNRVKPFSE NEARHFMHQI 120
ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180
EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PSFLSIEAKD 240
LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST 300
SISGSLFDKR RLLIGQPLPN KMTVFPKNKS STDFSSSGDG NSFYTQWGNQ ETSNSGRGRV 360
IQDAEERPHS RYLRRAYSSD RSGTSNSQSQ AKTYTMERCH SAEMLSVSKR SGGGENEESS 420
NHLCPGKTPF PFADPTPQTE TVQQWFGNLQ INAHLRKTTE YDSISPNRDF QGHPDLQKDT 480
SKNAWTDTKV KKNSDASDNA HSVKQQNTMK YMTALHSKPE IIQQECVFGS DPLSEQSKTR 540
GMEPPWGYQN RTLRSITSPL VAHRLKPIRQ KTKKAVVSIL DSEEITIYYP NGGRGFPLAD 600
RPPSPTDNIS RYSFDNLPEK YWRKYQYASR FVQLVRSKSP KITYFTRYAK CILMENSPGA 660
DFEVWFYDGV KIHKTEDFIQ VIEKTGKSYT LKSESEVNSL KEEIKMYMDH ANEGHRICLA 720
LESIISEEER KTRSAPFFPI IIGRKPGSTS SPKALSPPPS VDSNYPTRER ASFNRMVMHS 780
AASPTQAPIL NPSMVTNEGL GLTTTASGTD ISSNSLKDCL PKSAQLLKSV FVKNVGWATQ 840
LTSGAVWVQF NDGSQLVVQA GVSSISYTSP NGQTTRYGEN EKLPDYIKQK LQCLSSILLM 900
FSNPTPNFH 909 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000959; POLO_box_duplicated_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008266; Tyr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00659; POLO_box 
SMART
 SM00220; S_TKc 
PROSITE
 PS50078; POLO_BOX
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS