| Tag | Content |
|---|
| CPLM ID | CPLM-000292 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tumor necrosis factor receptor superfamily member 10B |
Protein Synonyms/Alias | Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262 |
Gene Name | TNFRSF10B |
Gene Synonyms/Alias | DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; UNQ160/PRO186 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 245 | KKVLPYLKGICSGGG | ubiquitination | [1, 2] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI. J Proteome Res. 2012 Feb 3;11(2):796-807. [ PMID: 22053931] |
Functional Description | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. |
Sequence Annotation | REPEAT 57 94 TNFR-Cys 1.
REPEAT 97 137 TNFR-Cys 2.
REPEAT 138 178 TNFR-Cys 3.
REPEAT 192 206 TAPE.
DOMAIN 339 422 Death.
DISULFID 81 94
DISULFID 97 113
DISULFID 116 129
DISULFID 119 137
DISULFID 139 153
DISULFID 156 170
DISULFID 160 178 |
Keyword | 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Direct protein sequencing; Disulfide bond; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 440 AA |
Protein Sequence | MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD 60
LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD 120
SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH 180
KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV 240
LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV 300
NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK 360
LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED 420
HLLSSGKFMY LEGNADSAMS 440 |
Gene Ontology | GO:0016021; C:integral to membrane; IC:UniProtKB. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0004872; F:receptor activity; NAS:UniProtKB. GO:0045569; F:TRAIL binding; NAS:UniProtKB. GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome. GO:0007250; P:activation of NF-kappaB-inducing kinase activity; NAS:UniProtKB. GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB. GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; NAS:UniProtKB. GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IMP:UniProtKB. GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB. |
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