CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030105
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bromodomain and PHD finger containing, 3 
Protein Synonyms/Alias
 Protein Brpf3 
Gene Name
 Brpf3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
89EQPQFPAKSKKPSSKacetylation[1]
100PSSKGKRKESCSKHAacetylation[1, 2]
105KRKESCSKHASGTSFacetylation[1, 2]
447KGVSKKGKMSLKQKIacetylation[1]
451KKGKMSLKQKIKKEPacetylation[1]
455MSLKQKIKKEPEEAGacetylation[1]
545DEKTSAVKEELKYWQacetylation[1, 2, 3]
549SAVKEELKYWQKLRHacetylation[2]
670NCMKYNAKDTIFHRAacetylation[1, 3]
794PQLLSLNKTVPNGELacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1204 AA 
Protein Sequence
MRKPRRKSRQ NAEGRRSPSP YSLKCSPTRE TLTYAQAQRI VEVDIDGRLH RISIYDPLKI 60
ITEDELTAQD ITECNSNKEN SEQPQFPAKS KKPSSKGKRK ESCSKHASGT SFHLPQPSFR 120
VVDTGSQPEA PPLPAAYYRY IEKPPEDLDA EVEYDMDEED IAWLDMVNEK RRADGHSSVS 180
ADTFELLVDR LEKESYLESR SSGAQQSLID EDAFCCVCLD DECHNSNVIL FCDICNLAVH 240
QECYGVPYIP EGQWLCRCCL QSPSRPVDCV LCPNKGGAFK QTSDGHWAHV VCAIWIPEVC 300
FANTVFLEPI EGIDNIPPAR WKLTCYICKQ KGLGAAIQCH KVNCYTAFHV TCAQRAGLFM 360
KIEPMRETSL NGTTFTVRKT AYCEAHSPSV AVARRKGDSP RSLSEVGDED GPKEGGGEEE 420
QEEAEEEGQE GQGGVGSPLK GVSKKGKMSL KQKIKKEPEE AGREAPSITL PMVTVPQIPS 480
YRLNKICSGL SFQRKTQFMQ RLHNYWLLKR QARNGVPLIR RLHSHLQSQR NAEQREQDEK 540
TSAVKEELKY WQKLRHDLER ARLLIELIRK REKLKREQVK VQQAAMELEL MPFTVLLRTT 600
LDLLQEKDSA HIFAEPVSLS EVPDYLEFIS KPMDFSTMRR KLESHLYHTL EEFEEDFNLI 660
VTNCMKYNAK DTIFHRAAVR LRDLGGAILR HARRQAENIG YDPERGTHLP ESPRLEDFYR 720
FSWEDVDNIL IPENRAHLSP EAQLKELLEK LDLVSTMRSS GARTRRVRML RREINALRQK 780
LAQPPPPQLL SLNKTVPNGE LPAGSRGDTA VLEQAQQEEP EEEGDRDDSK LPAPPTLEPT 840
GPAPSLSEQE SPPDPPTLKP ISDSKPSSRF LKSRKVEDEE LLEKSALQLG SEPLQCLLSD 900
NGIDRLSLTN PDSHPDTPLG TVGRRTSVLF KKAKNGVKLQ RGPDGTLENG EDHGPEDDPA 960
SPASTEDEHY SRKRPRSRSC SDSEGERSPQ QEEETGVTNG FGKHTESGSD SECSLGLSGG 1020
LAFEAGSGLT PPKRSRGKPA LSRVPFLEGV NGDSDHSGSG RSLLMPFEDH GDLEPLELVW 1080
AKCRGYPSYP ALIIDPKMPR EGLLHNGVPI PVPPLDVLKL GEQKQAEAGE RLFLVLFFDN 1140
KRTWQWLPRD KVLPLGVEDT VDKLKMLEGR KTSIRKSVQV AYDRAMIHLS RVRGSHAFVT 1200
SSYL 1204 
Gene Ontology
 GO:0070776; C:MOZ/MORF histone acetyltransferase complex; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043966; P:histone H3 acetylation; IEA:Compara. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR019542; Enhancer_polycomb-like_N.
 IPR000313; PWWP.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF10513; EPL1
 PF00855; PWWP 
SMART
 SM00297; BROMO
 SM00249; PHD
 SM00293; PWWP 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS50812; PWWP
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS
 PR00503; BROMODOMAIN.