UniProt Accession

 HDHD2_MOUSE; Q3UGR5; Q3U8M0; Q6PEB2; Q9CXN1; Q9DCF2 

Genbank Protein ID

 AK002837; AK014208; AK137285; AK147794; AK151285; AK152162; AK152259; BC058177 

Genbank Nucleotide ID

 BAB22395.1; BAB29206.1; BAE23293.1; BAE28142.1; BAE30270.1; BAE30997.1; BAE31078.1; AAH58177.1 

Protein Name

 Haloacid dehalogenase-like hydrolase domain-containing protein 2 

Protein Synonyms/Alias

  

Gene Name

 Hdhd2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
50	RFVTNTTKESKKDLL	acetylation	[1]
145	APLIAIHKARYYKRK	ubiquitination	[2]
152	KARYYKRKDGLALGP	ubiquitination	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 REGION 13 15 Substrate binding (By similarity).
 REGION 46 47 Substrate binding (By similarity).
 METAL 13 13 Magnesium.
 METAL 15 15 Magnesium; via carbonyl oxygen.
 METAL 204 204 Magnesium (By similarity).
 BINDING 179 179 Substrate.  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR023214; HAD-like_dom.
 IPR006357; HAD-SF_hydro_IIA.
 IPR006355; HAD-SF_hydro_IIA_hyp2.
 IPR023215; NPhePase-like_dom. 

Pfam

 PF13344; Hydrolase_6 

SMART

  

PROSITE

  

PRINTS