UniProt Accession

 PDIA5_MOUSE; Q921X9 

Genbank Protein ID

 BC009151 

Genbank Nucleotide ID

 AAH09151.1 

Protein Name

 Protein disulfide-isomerase A5 

Protein Synonyms/Alias

 Protein disulfide isomerase-related protein 

Gene Name

 Pdia5 

Gene Synonyms/Alias

 Pdir 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
96	RKLCKKMKVDLSPKD	acetylation	[1]
134	KSIVAFLKDPKGPPL	acetylation	[1]
137	VAFLKDPKGPPLWEE	acetylation	[2]
192	RIMPHFQKAATQVRG	acetylation	[1]
233	PTICYFEKGRFLFPY	acetylation	[1]
446	DAFKEDRKIACAAVD	acetylation	[1]
458	AVDCVKDKNQDLCQQ	acetylation	[3]
485	HYGKLVEKYESDRTE	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

 DOMAIN 132 259 Thioredoxin 1.
 DOMAIN 268 382 Thioredoxin 2.
 DOMAIN 376 504 Thioredoxin 3.
 MOTIF 514 517 Prevents secretion from ER (Potential).
 DISULFID 180 183 Redox-active (By similarity).
 DISULFID 303 306 Redox-active (By similarity).
 DISULFID 424 427 Redox-active (By similarity).  

Keyword

 Complete proteome; Disulfide bond; Endoplasmic reticulum; Isomerase; Redox-active center; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 517 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0003756; F:protein disulfide isomerase activity; IEA:EC.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:GOC.
 GO:0006950; P:response to stress; IDA:UniProtKB. 

Interpro

 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.