| Tag | Content |
|---|
| CPLM ID | CPLM-024680 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | High mobility group nucleosome-binding domain-containing protein 5 |
Protein Synonyms/Alias | Nucleosome-binding protein 1 |
Gene Name | Hmgn5 |
Gene Synonyms/Alias | Nsbp1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 33 | VPFTPELKPKRASTS | acetylation | [1] | | 35 | FTPELKPKRASTSRK | acetylation | [1] | | 44 | ASTSRKTKTTNVVEE | acetylation | [1] | | 53 | TNVVEESKDAGATTI | acetylation | [1] | | 64 | ATTIPETKPEVVKGE | acetylation | [1] | | 91 | IIEAPISKMETEEVK | acetylation | [1] | | 112 | TEGDGGEKKEAVVTK | acetylation | [1] | | 119 | KKEAVVTKGKNDELE | acetylation | [1] | | 121 | EAVVTKGKNDELEAN | acetylation | [1] | | 360 | DLHEEEGKEDLHEED | acetylation | [1] | | 422 | DFKEDGEKGEPVSTV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction (By similarity). |
Sequence Annotation | MOD_RES 18 18 Phosphoserine (By similarity).
MOD_RES 22 22 Phosphoserine (By similarity).
MOD_RES 29 29 Phosphothreonine (By similarity). |
Keyword | Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 429 AA |
Protein Sequence | MPKRKAAGDA SQEPKRRSAR LSAMPVPFTP ELKPKRASTS RKTKTTNVVE ESKDAGATTI 60
PETKPEVVKG ECNMENAENG EAKIIEAPIS KMETEEVKEQ INEDTEGDGG EKKEAVVTKG 120
KNDELEANIQ DVEKDEDEKE HEDTGEEGED GEREGGLKEK PDVAEIEDAK EAKDDEEKED 180
KEKEDDKGGD GKKEEEKDDE GEAETEEEVK EQQKEETEGD DGKCKVEENK EGRKESQHEE 240
EGKEELHEED GKEDLHEEDG KEDLHEEDGK EDLHEEEGKE DLHEEEGKED LHEEEGKEDL 300
HEEEGKEDLH EEEGKEDLHE EEGKEDLHEE EGKEDLHEED GKEGQHEEEG KEDLHEEEGK 360
EDLHEEDGKE GQHEEDGKKK ADGNEDRKEE EEQEAATEGN DENKVEVEEE ADNKDFKEDG 420
EKGEPVSTV 429 |
Gene Ontology | GO:0000785; C:chromatin; IEA:InterPro. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0031492; F:nucleosomal DNA binding; IEA:InterPro. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |