| Tag | Content |
|---|
| CPLM ID | CPLM-005196 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gamma-aminobutyric acid receptor subunit alpha-2 |
Protein Synonyms/Alias | GABA(A) receptor subunit alpha-2 |
Gene Name | Gabra2 |
Gene Synonyms/Alias | Gabra-2 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 389 | PVLSTISKSATTPEP | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. |
Sequence Annotation | CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
CARBOHYD 138 138 N-linked (GlcNAc...) (Potential).
DISULFID 166 180 By similarity. |
Keyword | Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 451 AA |
Protein Sequence | MRTKLSTCNV WFPLLVLLVW NPARLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG 60
LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNSMASK 120
IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC 180
PLKFGSYAYT TSEVTYIWTY NPSDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM 240
TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 300
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKKKEKGSV 360
MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM 420
SRIVFPVLFG TFNLVYWATY LNREPVLGVS P 451 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW. GO:0032590; C:dendrite membrane; IDA:BHF-UCL. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW. GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. GO:0004890; F:GABA-A receptor activity; TAS:RGD. GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |