CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004560
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Atrial natriuretic peptide receptor 3 
Protein Synonyms/Alias
 Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C 
Gene Name
 NPR3 
Gene Synonyms/Alias
 ANPRC; C5orf23; NPRC 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
456KYPWGPLKLRIDENRubiquitination[1]
Reference
 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572
Functional Description
 Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. 
Sequence Annotation
 BINDING 106 106 Chloride.
 BINDING 135 135 Chloride; via amide nitrogen.
 BINDING 136 136 Chloride; via amide nitrogen.
 CARBOHYD 86 86 N-linked (GlcNAc...) (complex).
 CARBOHYD 293 293 N-linked (GlcNAc...) (high mannose).
 CARBOHYD 394 394 N-linked (GlcNAc...) (complex).
 DISULFID 108 136
 DISULFID 213 261
 DISULFID 473 473 Interchain.  
Keyword
 3D-structure; Alternative splicing; Chloride; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 541 AA 
Protein Sequence
MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP QKIEVLVLLP 60
QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ VAYEDSDCGN RALFSLVDRV 120
AAARGAKPDL ILGPVCEYAA APVARLASHW DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA 180
YAKMGEMMLA LFRHHHWSRA ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK 240
DLDLEDIVRN IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG 300
SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM EDYVNMFVEG 360
FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI AGQVSIDANG DRYGDFSVIA 420
MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY PWGPLKLRID ENRIVEHTNS SPCKSSGGLE 480
ESAVTGIVVG ALLGAGLLMA FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV 540
A 541 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IC:BHF-UCL.
 GO:0008528; F:G-protein coupled peptide receptor activity; ISS:BHF-UCL.
 GO:0016941; F:natriuretic peptide receptor activity; IDA:UniProtKB.
 GO:0017046; F:peptide hormone binding; ISS:BHF-UCL.
 GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0007194; P:negative regulation of adenylate cyclase activity; IEA:Compara.
 GO:0002158; P:osteoclast proliferation; ISS:UniProtKB.
 GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; ISS:BHF-UCL.
 GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.
 GO:0008217; P:regulation of blood pressure; ISS:UniProtKB.
 GO:0033688; P:regulation of osteoblast proliferation; ISS:UniProtKB.
 GO:0001501; P:skeletal system development; ISS:UniProtKB. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR001170; Ntpep_rcpt. 
Pfam
 PF01094; ANF_receptor 
SMART
  
PROSITE
 PS00458; ANF_RECEPTORS 
PRINTS
 PR00255; NATPEPTIDER.