| Tag | Content |
|---|
| CPLM ID | CPLM-022248 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase FANCL |
Protein Synonyms/Alias | Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43 |
Gene Name | FANCL |
Gene Synonyms/Alias | PHF9 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 22 | LLPQNRSKTVYEGFI | ubiquitination | [1] | | 49 | LPEDLQLKNARLLCS | ubiquitination | [1] | | 266 | LGADHVVKPLGIKLS | ubiquitination | [1] | | 271 | VVKPLGIKLSRNIHL | ubiquitination | [1] | | 369 | GECPYCSKPITLKMS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. |
Sequence Annotation | ZN_FING 307 365 RING-type.
REGION 104 294 UBC-RWD region (URD). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; DNA damage; DNA repair; Fanconi anemia; Ligase; Metal-binding; Nucleus; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 375 AA |
Protein Sequence | MAVTEASLLR QCPLLLPQNR SKTVYEGFIS AQGRDFHLRI VLPEDLQLKN ARLLCSWQLR 60
TILSGYHRIV QQRMQHSPDL MSFMMELKML LEVALKNRQE LYALPPPPQF YSSLIEEIGT 120
LGWDKLVYAD TCFSTIKLKA EDASGREHLI TLKLKAKYPA ESPDYFVDFP VPFCASWTPQ 180
VNSPQSSLIS IYSQFLAAIE SLKAFWDVMD EIDEKTWVLE PEKPPRSATA RRIALGNNVS 240
INIEVDPRHP TMLPECFFLG ADHVVKPLGI KLSRNIHLWD PENSVLQNLK DVLEIDFPAR 300
AILEKSDFTM DCGICYAYQL DGTIPDQVCD NSQCGQPFHQ ICLYEWLRGL LTSRQSFNII 360
FGECPYCSKP ITLKMSGRKH 380 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB. GO:0005635; C:nuclear envelope; IEA:Compara. GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006281; P:DNA repair; IMP:UniProtKB. GO:0007276; P:gamete generation; IEA:Compara. GO:0006513; P:protein monoubiquitination; IDA:UniProtKB. GO:0042127; P:regulation of cell proliferation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |