UniProt Accession

 FZD1_HUMAN; Q9UP38; A4D1E8; O94815; Q549T8 

Genbank Protein ID

 AF072872; AB017363; AC084381; CH236949; CH471091; BC051271 

Genbank Nucleotide ID

 AAD41636.1; BAA34666.1; AAS02008.1; EAL24161.1; EAW76871.1; AAH51271.1 

Protein Name

 Frizzled-1 

Protein Synonyms/Alias

 Fz-1; hFz1; FzE1 

Gene Name

 FZD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
641	YTRLTNSKQGETTV*	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. 

Sequence Annotation

 DOMAIN 111 230 FZ.
 MOTIF 625 630 Lys-Thr-X-X-X-Trp motif, mediates
 MOTIF 645 647 PDZ-binding.
 CARBOHYD 130 130 N-linked (GlcNAc...) (Potential).
 CARBOHYD 231 231 N-linked (GlcNAc...) (Potential).
 DISULFID 116 177 By similarity.
 DISULFID 124 170 By similarity.
 DISULFID 161 198 By similarity.
 DISULFID 187 227 By similarity.
 DISULFID 191 215 By similarity.  

Keyword

 Cell membrane; Complete proteome; Developmental protein; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 647 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IBA:RefGenome.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0032589; C:neuron projection membrane; IBA:RefGenome.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0042813; F:Wnt-activated receptor activity; IDA:BHF-UCL.
 GO:0035425; P:autocrine signaling; IDA:BHF-UCL.
 GO:0007409; P:axonogenesis; IBA:RefGenome.
 GO:0007420; P:brain development; IBA:RefGenome.
 GO:0044338; P:canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation; IMP:BHF-UCL.
 GO:0044339; P:canonical Wnt receptor signaling pathway involved in osteoblast differentiation; IMP:BHF-UCL.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0030855; P:epithelial cell differentiation; IBA:RefGenome.
 GO:0007199; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; IBA:RefGenome.
 GO:0008406; P:gonad development; IBA:RefGenome.
 GO:0060022; P:hard palate development; IEA:Compara.
 GO:0048286; P:lung alveolus development; IBA:RefGenome.
 GO:0003149; P:membranous septum morphogenesis; IEA:Compara.
 GO:0003150; P:muscular septum morphogenesis; IEA:Compara.
 GO:0030514; P:negative regulation of BMP signaling pathway; IBA:RefGenome.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IBA:RefGenome.
 GO:0035414; P:negative regulation of catenin import into nucleus; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IEA:Compara.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0042493; P:response to drug; IMP:BHF-UCL.
 GO:0001944; P:vasculature development; IBA:RefGenome.
 GO:0007223; P:Wnt receptor signaling pathway, calcium modulating pathway; IBA:RefGenome. 

Interpro

 IPR000539; Frizzled.
 IPR015526; Frizzled/SFRP.
 IPR020067; Frizzled_dom.
 IPR026548; FZD1.
 IPR017981; GPCR_2-like. 

Pfam

 PF01534; Frizzled
 PF01392; Fz 

SMART

 SM00063; FRI 

PROSITE

 PS50038; FZ
 PS50261; G_PROTEIN_RECEP_F2_4 

PRINTS

 PR00489; FRIZZLED.