CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038213
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Hydroxyacylglutathione hydrolase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Hagh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
158EYTVNNLKFARHVEPacetylation[1, 2]
158EYTVNNLKFARHVEPsuccinylation[1]
158EYTVNNLKFARHVEPubiquitination[3]
180KLAWAKEKYAIGEPTubiquitination[3]
207PFMRVKEKTVQQHAGacetylation[2]
207PFMRVKEKTVQQHAGubiquitination[3]
229MRAIRREKDQFKVPRacetylation[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 237 AA 
Protein Sequence
MVLGRGSLCL RSLSALGATC ARRGLGQALL GLSLCHSDFR KNLTVQQDIM KVYGGDDRIG 60
ALTHKVTHLS TLQVGSLSVK CLSTPCHTSG HICYFVSKPG SSEPSAVFTG DTLFVAGCGK 120
FYEGTADEMY KALLEVLGRL PPDTKVYCGH EYTVNNLKFA RHVEPGNAAI QEKLAWAKEK 180
YAIGEPTVPS TLAEEFTYNP FMRVKEKTVQ QHAGETDPVT TMRAIRREKD QFKVPRD 237 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006750; P:glutathione biosynthetic process; IC:MGI. 
Interpro
 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 
Pfam
 PF00753; Lactamase_B 
SMART
 SM00849; Lactamase_B 
PROSITE
  
PRINTS