UniProt Accession

 DDX55_HUMAN; Q8NHQ9; Q658L6; Q9HCH7 

Genbank Protein ID

 AC055713; AC117503; BC030020; AL833756; AB046815 

Genbank Nucleotide ID

 AAH30020.1; CAH56233.1; BAB13421.1 

Protein Name

 ATP-dependent RNA helicase DDX55 

Protein Synonyms/Alias

 DEAD box protein 55 

Gene Name

 DDX55 

Gene Synonyms/Alias

 KIAA1595 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	IPLFMRNKDVAAEAV	ubiquitination	[1]
152	LEDMFRRKAEGLDLA	ubiquitination	[1]
316	KIFMEFRKLQSGILV	ubiquitination	[2]
444	CNLIFRLKDLDFASL	acetylation	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Probable ATP-binding RNA helicase. 

Sequence Annotation

 DOMAIN 40 223 Helicase ATP-binding.
 DOMAIN 254 402 Helicase C-terminal.
 NP_BIND 53 60 ATP (By similarity).
 MOTIF 9 37 Q motif.
 MOTIF 171 174 DEAD box.
 MOD_RES 544 544 Phosphoserine.
 MOD_RES 594 594 Phosphoserine.  

Keyword

 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 600 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 

Interpro

 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR025313; DUF4217.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 

Pfam

 PF00270; DEAD
 PF13959; DUF4217
 PF00271; Helicase_C 

SMART

 SM00487; DEXDc
 SM00490; HELICc 

PROSITE

 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 

PRINTS