UniProt Accession

 BZW1_HUMAN; Q7L1Q6; B4DLZ8; B4DWF7; Q14281; Q15394; Q9BUY0 

Genbank Protein ID

 D13630; AK297227; AK301511; AC007163; BC001804; BC026303; Z70221 

Genbank Nucleotide ID

 BAA02795.2; BAG59710.1; BAG63019.1; AAX93286.1; AAH01804.1; AAH26303.1; CAA94180.1 

Protein Name

 Basic leucine zipper and W2 domain-containing protein 1 

Protein Synonyms/Alias

 Protein Orf 

Gene Name

 BZW1 

Gene Synonyms/Alias

 BZAP45; KIAA0005 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	FLDASGAKLDYRRYA	ubiquitination	[1, 2]
140	KKLLLFLKGFSESER	ubiquitination	[1, 2]
197	FKSWINEKDINAVAA	ubiquitination	[1, 2]
223	MELFPANKQSVEHFT	ubiquitination	[1, 2]
231	QSVEHFTKYFTEAGL	ubiquitination	[1]
239	YFTEAGLKELSEYVR	ubiquitination	[1, 2]
255	QQTIGARKELQKELQ	ubiquitination	[1]
259	GARKELQKELQEQMS	ubiquitination	[1, 2]
272	MSRGDPFKDIILYVK	ubiquitination	[1, 2]
309	STVEWNKKEELVAEQ	ubiquitination	[2]
368	KIVVLFYKAEVLSEE	ubiquitination	[3]
379	LSEEPILKWYKDAHV	ubiquitination	[1, 2, 4]
399	VFLEQMKKFVEWLKN	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Enhances histone H4 gene transcription but does not seem to bind DNA directly. 

Sequence Annotation

 DOMAIN 247 414 W2.
 MOD_RES 411 411 Phosphoserine.
 MOD_RES 413 413 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 419 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016024; ARM-type_fold.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003307; W2_domain. 

Pfam

 PF02020; W2 

SMART

 SM00515; eIF5C 

PROSITE

 PS51363; W2 

PRINTS