UniProt Accession

 ZBED1_HUMAN; O96006; Q96BY4 

Genbank Protein ID

 Y16947; Y17156; AB018328; AC079176; BC015030 

Genbank Nucleotide ID

 CAA76545.1; CAA76660.1; BAA34505.2; AAH15030.1 

Protein Name

 Zinc finger BED domain-containing protein 1 

Protein Synonyms/Alias

 Putative Ac-like transposable element; dREF homolog 

Gene Name

 ZBED1 

Gene Synonyms/Alias

 ALTE; DREF; KIAA0785; TRAMP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
113	GQDALAVKAGHGYDS	ubiquitination	[1, 2]
607	LLPKVLQKYWCVTAT	ubiquitination	[1, 2, 3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity. 

Sequence Annotation

 ZN_FING 20 78 BED-type.  

Keyword

 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 694 AA 

Protein Sequence

Gene Ontology

 GO:0000228; C:nuclear chromosome; TAS:ProtInc.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004803; F:transposase activity; TAS:ProtInc. 

Interpro

 IPR008906; HATC.
 IPR012337; RNaseH-like_dom.
 IPR003656; Znf_BED_prd. 

Pfam

 PF05699; Dimer_Tnp_hAT
 PF02892; zf-BED 

SMART

 SM00614; ZnF_BED 

PROSITE

 PS50808; ZF_BED 

PRINTS