CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015730
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial 
Protein Synonyms/Alias
 MMSDH; Malonate-semialdehyde dehydrogenase [acylating] 
Gene Name
 CG17896 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
33TKLFIDGKFVESKTNacetylation[1]
107ENMGELAKNITKEQGacetylation[1]
115NITKEQGKTLADAEGacetylation[1]
253VGSDQAGKYIYERAGacetylation[1]
362DLIESGVKEGAKLILacetylation[1]
486GDHHFYGKQGIKFYTacetylation[1]
490FYGKQGIKFYTQTKTacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). 
Sequence Annotation
 NP_BIND 195 199 NAD (Potential).
 NP_BIND 247 252 NAD (Potential).
 ACT_SITE 303 303 Nucleophile (By similarity).
 BINDING 403 403 NAD (Potential).  
Keyword
 Alternative splicing; Complete proteome; Mitochondrion; NAD; Oxidoreductase; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MSLVRLIGAE ARHLAKRSYS SAAPTTKLFI DGKFVESKTN EWIDVHDPAT NQVVTRVPKA 60
TQAEMQAALE SNKKAFRSWS NQSILTRQQV MFKLQALIKE NMGELAKNIT KEQGKTLADA 120
EGDVLRGLQV VEHCCSIPSL QMGETVANVA RDMDTYSLVL PLGVTAGVAP FNFPAMIPLW 180
MFPVAITTGN TMLLKPSERV PGATMLLMEL LNEAGCPPGV VNVIHGQHDA VNFICDAPEI 240
KAVSFVGSDQ AGKYIYERAG KNGKRVQSNM GAKNHGIILG DANKENTLNQ LAGAAFGAAG 300
QRCMALSTAV FVGDAQAWIP DLVERAQKLK VNAGHVPGTD VGPVISAASR QRINDLIESG 360
VKEGAKLILD GRKITVPGYE DGYFVGPTIL SDVTPSMKCY TEEIFGPVLV ILKADTLDDA 420
IGIVNANPYG NGTAVFTTNG AAARKFVNEI DAGQVGVNVP IPVPLPMFSF TGTRGSFRGD 480
HHFYGKQGIK FYTQTKTVTQ LWRKTDVTHT QAAVAMPTMK 520 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0000062; F:fatty-acyl-CoA binding; ISS:UniProtKB.
 GO:0018478; F:malonate-semialdehyde dehydrogenase (acetylating) activity; ISS:UniProtKB.
 GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating) activity; ISS:UniProtKB.
 GO:0019859; P:thymine metabolic process; ISS:UniProtKB.
 GO:0006573; P:valine metabolic process; ISS:UniProtKB. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010061; MeMal-semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS