CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000574
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exocyst complex component 4 
Protein Synonyms/Alias
 Exocyst complex component Sec8 
Gene Name
 Exoc4 
Gene Synonyms/Alias
 Sec8; Sec8l1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
9AAEAAGGKYRSTVSKacetylation[1]
18RSTVSKSKDPSGLLIacetylation[1]
241SNIPTPRKFLDASQYubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 238 238 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Exocytosis; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 975 AA 
Protein Sequence
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA YEKCDRDLDE 60
LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC KMLLHCKRDE LRKLWIEGIE 120
HKHVLNLLDE IENIKQVPQK LEQCMASKHY LSATDMLVSA VESLEGPLLQ VEGLSDLRLE 180
LHSKKMNLHL VLIEELHRHL YIKSTSRVVQ RNKEKGKMSS HGKDPSPGPL IDVSNIPTPR 240
KFLDASQYSA AGGSSVREMN LQDVKEDLEC DPEENSTLFM GILIQGLARL KKIPETVKAI 300
KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF NAVATAHSVV 360
LGYLQDSVGT QLTQQEEIKL YDMADVWVKI QDVLQMLLTE YLDMKNTRTA SEPSAQLSYA 420
STGREFAAFF AKKKPQRPKN SLFKFESSSH AISMSAYLRE QRRELYSRSG ELQGGPDDNL 480
IEGGGTKFVC KPGARNITVI FHPLLRFIQE IEHALGLGPA KQCPLREFLT VYIKSIFLNQ 540
VLAEINKEIE GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA 600
YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL KSLPNWTNMA 660
QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD ILRDVSDLKA LANMHESLEW 720
LAGRTKSAFS NLSTSQMLSP AQESHVNMDL PPVSEQIMQT LSELAKTFQD MADRCLLVLH 780
LEVRVHCFHY LIPLAKEGNY AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY 840
IFEGLGHLIS CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY 900
EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL QRLKEIICEQ 960
AAIKQATKDK KITTV 975 
Gene Ontology
 GO:0000145; C:exocyst; IEA:InterPro.
 GO:0032584; C:growth cone membrane; IDA:MGI.
 GO:0035748; C:myelin sheath abaxonal region; IDA:BHF-UCL.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR007191; Sec8_exocyst. 
Pfam
 PF04048; Sec8_exocyst 
SMART
  
PROSITE
  
PRINTS