CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043182
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 S-formylglutathione hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Esd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
4****MALKQISSNRCacetylation[1, 2, 3, 4]
4****MALKQISSNRCsuccinylation[4]
4****MALKQISSNRCubiquitination[5]
17RCFGGLQKVFEHSSVubiquitination[5]
27EHSSVELKCKMRFAVacetylation[2]
27EHSSVELKCKMRFAVubiquitination[5]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 135 AA 
Protein Sequence
MALKQISSNR CFGGLQKVFE HSSVELKCKM RFAVYLPPQA ESGKCPALYW LSGLTCTEQN 60
FISKSGYQQA ASEHGLVVIA PDTSPRGCNI KGEDDSWDFG TGAGFYVNAT EDPWKANYRM 120
YSYVTEEAYD ATCLV 135 
Gene Ontology
 GO:0004091; F:carboxylesterase activity; IEA:InterPro.
 GO:0016788; F:hydrolase activity, acting on ester bonds; IDA:MGI.
 GO:0018738; F:S-formylglutathione hydrolase activity; IEA:InterPro.
 GO:0046294; P:formaldehyde catabolic process; IEA:InterPro. 
Interpro
 IPR000801; Esterase_put.
 IPR014186; S-formylglutathione_hydrol. 
Pfam
 PF00756; Esterase 
SMART
  
PROSITE
  
PRINTS