UniProt Accession

 DOPD_RAT; P80254 

Genbank Protein ID

 Z36980 

Genbank Nucleotide ID

 CAA85429.1 

Protein Name

 D-dopachrome decarboxylase 

Protein Synonyms/Alias

 D-dopachrome tautomerase 

Gene Name

 Ddt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
33	ATATILDKPEDRVSV	acetylation	[1]
110	LEPWQIGKKGTVMTF	acetylation	[1]
111	EPWQIGKKGTVMTFL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). 

Sequence Annotation

 MOD_RES 2 2 N-acetylproline (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Melanin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0033981; F:D-dopachrome decarboxylase activity; IEA:EC.
 GO:0004167; F:dopachrome isomerase activity; TAS:RGD.
 GO:0006954; P:inflammatory response; NAS:RGD.
 GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR001398; Macrophage_inhib_fac.
 IPR019829; Macrophage_inhib_fac_CS.
 IPR014347; Tautomerase/MIF_sf. 

Pfam

 PF01187; MIF 

SMART

  

PROSITE

 PS01158; MIF 

PRINTS