CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014477
UniProt Accession
Genbank Protein ID
 U53706 
Genbank Nucleotide ID
Protein Name
 Diphosphomevalonate decarboxylase 
Protein Synonyms/Alias
 Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase 
Gene Name
 Mvd 
Gene Synonyms/Alias
 Mpd 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
5***MASEKPQDLMVTacetylation[1]
342ANGDKFLKGLQVAPVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Performs the first committed step in the biosynthesis of isoprenes. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; ATP-binding; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Lipid biosynthesis; Lipid metabolism; Lyase; Nucleotide-binding; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 401 AA 
Protein Sequence
MASEKPQDLM VTCTAPVNIA VIKYWGKRDE ALILPINPSL SVTLHQDQLK TTTTAAISKD 60
FTEDRIWLNG REEDVGQPRL QACLREIRRL ARKRRSTGDG DALPLSLGYK VHVASVNNFP 120
TAAGLASSAA GYACLAYTLA RVYGVEGDLS EVARRGSGSA CRSLYGGFVE WQMGEQADGK 180
DSIARQIAPE WHWPQLRVLI LVVSAEKKPT GSTVGMQTSV ATSTLLKFRA ESIVPERMKE 240
MTRCIQEQDF QAFAQLTMKD SNQFHATCLD TFPPISYLND TSRRIIQLVH RFNAHHGQTK 300
VAYTFDAGPN AVIFTLEDTV AEFVAAVRHS FPPAANGDKF LKGLQVAPVL LSDELKTSLA 360
TEPSPGGVQY IIATQVGPGP QVLDDPHHHL LGPDGLPQRD L 401 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005782; C:peroxisomal matrix; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004163; F:diphosphomevalonate decarboxylase activity; IDA:RGD.
 GO:0006695; P:cholesterol biosynthetic process; NAS:RGD.
 GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IDA:RGD.
 GO:0042493; P:response to drug; IEP:RGD. 
Interpro
 IPR006204; GHMP_kinase_N_dom.
 IPR005935; Mev_diP_decarb.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF00288; GHMP_kinases_N 
SMART
  
PROSITE
  
PRINTS