CPLM-015405

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-015405

UniProt Accession

KCNT2_HUMAN; Q6UVM3; Q3SY59; Q5VTN1; Q6ZMT3

Genbank Protein ID

AY359444; AK131498; BX647852; AL358853; AL138931; AL139137; AL591604; AL358853; AL138931; AL139137; AL591604; AL591604; AL138931; AL139137; AL358853; AL591604; AL138931; AL139137; AL358853; AL138931; AL139137; AL358853; AL591604; AL138931; AL139137; AL358853; AL591604; AL139137; AL138931; AL358853; AL591604; AL139137; AL138931; AL358853; AL591604; BC103948; BC103949; BC103950

Genbank Nucleotide ID

AAR06170.1; BAD18642.1; CAI46099.1; CAH71957.1; CAH71957.1; CAH71957.1; CAH71957.1; CAH71958.1; CAH71958.1; CAH71958.1; CAH71958.1; CAH72932.1; CAH72932.1; CAH72932.1; CAH72932.1; CAH72933.1; CAH72933.1; CAH72933.1; CAH72933.1; CAI15623.1; CAI15623.1; CAI15623.1; CAI15623.1; CAI15624.1; CAI15624.1; CAI15624.1; CAI15624.1; CAI16091.1; CAI16091.1; CAI16091.1; CAI16091.1; CAI16092.1; CAI16092.1; CAI16092.1; CAI16092.1; AAI03949.1; AAI03950.1; AAI03951.1

Protein Name

Potassium channel subfamily T member 2

Protein Synonyms/Alias

Sequence like an intermediate conductance potassium channel subunit; Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1

Gene Name

KCNT2

Gene Synonyms/Alias

SLICK

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
366	YLQGSALKDQDLLRA	ubiquitination	[1]
479	QSPEQWQKMYGRCSG	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.

Sequence Annotation

DOMAIN 422 543 RCK N-terminal.
NP_BIND 1025 1032 ATP (Potential).
CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).

Keyword

Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1135 AA

Protein Sequence

MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL FFIKNQRSSL 60
RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR SLPLWGLQVS VALISLFETI 120
LLGYLSYKGN IWEQILRIPF ILEIINAVPF IISIFWPSLR NLFVPVFLNC WLAKHALENM 180
INDLHRAIQR TQSAMFNQVL ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF 240
STVGFGDVTP ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK 300
HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI PMWSQRVIYL 360
QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI LRAWAVKDFA PNCPLYVQIL 420
KPENKFHIKF ADHVVCEEEF KYAMLALNCI CPATSTLITL LVHTSRGQEG QQSPEQWQKM 480
YGRCSGNEVY HIVLEESTFF AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP 540
RYIMNSTDIC FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID 600
LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ SEDETTPDEE 660
MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD KSCQHNYYED AKAYGFKNKL 720
IIVAAETAGN GLYNFIVPLR AYYRPKKELN PIVLLLDNPL DDLLRCGVTF AANMVVVDKE 780
STMSAEEDYM ADAKTIVNVQ TLFRLFSSLS IITELTHPAN MRFMQFRAKD CYSLALSKLE 840
KKERERGSNL AFMFRLPFAA GRVFSISMLD TLLYQSFVKD YMISITRLLL GLDTTPGSGF 900
LCSMKITADD LWIRTYARLY QKLCSSTGDV PIGIYRTESQ KLTTSESQIS ISVEEWEDTK 960
DSKEQGHHRS NHRNSTSSDQ SDHPLLRRKS MQWARRLSRK GPKHSGKTAE KITQQRLNLY 1020
RRSERQELAE LVKNRMKHLG LSTVGYDEMN DHQSTLSYIL INPSPDTRIE LNDVVYLIRP 1080
DPLAYLPNSE PSRRNSICNV TGQDSREETQ L 1111

Gene Ontology

GO:0008076; C:voltage-gated potassium channel complex; IBA:RefGenome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0015269; F:calcium-activated potassium channel activity; IBA:RefGenome.
GO:0005249; F:voltage-gated potassium channel activity; IBA:RefGenome.

Interpro

IPR013099; Ion_trans_2.
IPR003929; K_chnl_Ca-activ_BK_asu.
IPR016040; NAD(P)-bd_dom.

Pfam

PF03493; BK_channel_a
PF07885; Ion_trans_2

SMART

PROSITE

PS51201; RCK_N

PRINTS