CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025580
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial transmembrane GTPase FZO-2 
Protein Synonyms/Alias
  
Gene Name
 hfzo2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91EMQGYKDKLSIIGEVubiquitination[1, 2]
105VLSRRHMKVAFFGRTubiquitination[1]
178AHALHMDKDLKAGCLubiquitination[1, 2]
257KVNERLSKPNIFILNubiquitination[1, 2]
423NLLTLDVKKKIKEVTubiquitination[2]
519LPAGIQDKLHTLIPCubiquitination[1]
528HTLIPCKKFDLSYNLubiquitination[1, 2]
728EEIARLPKEIDQLEKubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Membrane; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 769 AA 
Protein Sequence
MSLVCHQFAC LSSTLVGAFL TLSPSSSIMA EPVSPLKHFV LAKKAITAIF DQLLEFVTEG 60
SHFVEATYKN PELDRIATED DLVEMQGYKD KLSIIGEVLS RRHMKVAFFG RTSSGKSSVI 120
NAMLWDKVLP SGIGHITNCF LSVEGTDGDK AYLMTEGSDE KKSVKTVNQL AHALHMDKDL 180
KAGCLVRVFC PKAKCALLRD DLVLVDSPGT DVTTELDSWI DKFCLDADVF VLVANSESTL 240
MNTEKHFFHK VNERLSKPNI FILNNRWDAS ASEPEYMEDV RRQHMERCLH FLVEELKVVN 300
ALEAQNRIFF VSAKEVLSAR KQKAQGMPES GVALAEGFHA RLQEFQNFEQ IFEECISQSA 360
VKTKFEQHTI RAKQILATVK NIMDSVNLAA EDKRHYSVEE REDQIDRLDF IRNQMNLLTL 420
DVKKKIKEVT EEVPNKVSCA MTDEICRLSV LVDEFCSEFH PNPDVLKIYK SELNKHIEDG 480
MGRNLADRCT DEVNALVLQT QQEIIENLKP LLPAGIQDKL HTLIPCKKFD LSYNLNYHKL 540
CSDFQEDIVF RFSLGWSSLV HRFLGPRNAQ RVLLGLSEPI FQLPRSLAST PTAPTTPATP 600
DNASQEELMI TLVTGLASVT SRTSMGIIIV GGVIWKTIGW KLLSVSLTMY GALYLYERLS 660
WTTHAKERAF KQQFVNYATE KLRMIVSSTS ANCSHQVKQQ IATTFARLCQ QVDITHKQLE 720
EEIARLPKEI DQLEKIQNNS KLLRNKAVQL ENELENFTKQ FLPSSNEES 769 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0008053; P:mitochondrial fusion; IEA:InterPro. 
Interpro
 IPR001401; Dynamin_GTPase.
 IPR006884; Fzo/mitofusin_HR2.
 IPR027088; Mitofusin-1.
 IPR027094; Mitofusin_fam.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00350; Dynamin_N
 PF04799; Fzo_mitofusin 
SMART
  
PROSITE
  
PRINTS