| Tag | Content |
|---|
| CPLM ID | CPLM-024269 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histidine-specific methyltransferase EgtD |
Protein Synonyms/Alias | Histidine-alpha-N-methyltransferase |
Gene Name | egtD |
Gene Synonyms/Alias | MSMEG_6247; MSMEI_6086 |
Created Date | July 27, 2013 |
Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
NCBI Taxa ID | 246196 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 242 | DAFEHVAKWNSDEER | pupylation | [1] |
|
Reference | [1] Proteome-wide identification of mycobacterial pupylation targets. Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH. Mol Syst Biol. 2010 Jul 13;6:386. [ PMID: 20631680] |
Functional Description | Catalyzes the methylations of histidine to form N- alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine). Histidine and alpha-N,N-dimethylhistidine are preferred substrates. |
Sequence Annotation | |
Keyword | Complete proteome; Methyltransferase; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 321 AA |
Protein Sequence | MTLSLANYLA ADSAAEALRR DVRAGLTAAP KSLPPKWFYD AVGSDLFDQI TRLPEYYPTR 60
TEAQILRTRS AEIIAAAGAD TLVELGSGTS EKTRMLLDAM RDAELLRRFI PFDVDAGVLR 120
SAGAAIGAEY PGIEIDAVCG DFEEHLGKIP HVGRRLVVFL GSTIGNLTPA PRAEFLSTLA 180
DTLQPGDSLL LGTDLVKDTG RLVRAYDDAA GVTAAFNRNV LAVVNRELSA DFDLDAFEHV 240
AKWNSDEERI EMWLRARTAQ HVRVAALDLE VDFAAGEEML TEVSCKFRPE NVVAELAEAG 300
LRQTHWWTDP AGDFGLSLAV R 321 |
Gene Ontology | GO:0030745; F:dimethylhistidine N-methyltransferase activity; IEA:EC. GO:0008276; F:protein methyltransferase activity; IDA:UniProtKB. GO:0052704; P:ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine; IDA:UniProtKB. GO:0052707; P:N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |