| Tag | Content |
|---|
| CPLM ID | CPLM-006988 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proteasome component ECM29 |
Protein Synonyms/Alias | Extracellular mutant protein 29 |
Gene Name | ECM29 |
Gene Synonyms/Alias | YHL030W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 85 | RALIVQAKEPNLAAQ | ubiquitination | [1] | | 1263 | ARSIDVEKGVNPTKS | ubiquitination | [1] | | 1697 | DDSEGSIKQTSDEST | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Stabilizes the proteasome holoenzyme, probably by tethering the 20S proteolytic core particle and the 19S regulatory particle. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. |
Sequence Annotation | REPEAT 32 69 HEAT 1.
REPEAT 116 153 HEAT 2.
REPEAT 256 292 HEAT 3.
REPEAT 313 351 HEAT 4.
REPEAT 384 422 HEAT 5.
REPEAT 439 476 HEAT 6.
REPEAT 590 627 HEAT 7.
REPEAT 707 745 HEAT 8.
REPEAT 748 780 HEAT 9.
REPEAT 781 818 HEAT 10.
REPEAT 846 885 HEAT 11.
REPEAT 945 982 HEAT 12.
REPEAT 988 1025 HEAT 13.
REPEAT 1030 1067 HEAT 14.
REPEAT 1137 1174 HEAT 15.
REPEAT 1178 1215 HEAT 16.
REPEAT 1272 1311 HEAT 17.
REPEAT 1361 1398 HEAT 18.
REPEAT 1422 1459 HEAT 19.
REPEAT 1503 1540 HEAT 20.
REPEAT 1544 1581 HEAT 21.
REPEAT 1649 1687 HEAT 22.
REPEAT 1746 1785 HEAT 23.
REPEAT 1830 1867 HEAT 24.
MOD_RES 1692 1692 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1868 AA |
Protein Sequence | MSISSDEAKE KQLVEKAELR LAIADSPQKF ETNLQTFLPP LLLKLASPHA SVRTAVFSAL 60
KNLISRINTL PQVQLPVRAL IVQAKEPNLA AQQDSTNVRL YSLLLASKGI DRLSLQDRQQ 120
LLPLVVSNIS CLTGTVAARM FHILLKLILE WVAPQESSHE QEEFVQFLQL DNDGFSFLMR 180
QFTRFFLLVP SKQVQVSQQP LSRGYTCPGL SLTDVAFFTY DAGVTFNKEQ LNKFKKAIFQ 240
FVCRGMAATQ TIEQSPRMIE LMEFLCVVST DSTNLSDDAA QFMKRFPMPY ENEEFITFLQ 300
TLYIGNTANG RPPVKAILQE KILSILNRSH FATTKAECIS LICSIGLHSS EYKLRSLTLS 360
FIRHVAKLNY KNLNPASSSP SSTDFSTCIV SLIRNNLHAE GWPKLQLGPQ TPAFNTAILQ 420
RQLQYETLGD ILKRDFELVS DLSYIEFLFE SLKNDLPQFR SSIQESLLSL VGHLSILPQQ 480
SKLKLKNLLR KNLSIDEQQR EDNNDAVNSI MALKFVSIKF TNAAFPFHDP EARLFNIWGT 540
VRTNRFDIIE ESFKGLQPFW FRVNNASINT SATVKTSDLL GSHLSETEFP PFREFLQVLI 600
DQLDSEAASI TRKSLNNAVR FSKQCLISNA IYGKKTMVIQ DEDWSVRIDK ALELDDTVVS 660
RVNEMVQGMN DDIFIRYLTL LSNEFTATNS KGEQIAIFPY QDPIFGSVLL TLLNFVSNNV 720
LRRLEILVPD LYHLVIMKFQ SLSDNDLAVC ATIIGIISTA IADSTHVKRI TKIAQSQTMA 780
ETYVASYVVP RLYLKDQTNH IESDSILNLL NILTTHLSHP GTNKDMILKL VCQVTKFGLL 840
LQVSAQERKD FLKKVMDTIQ DKLINDVTAI QTWSYLSLYS TDLENSSLFQ EKLLETNVSK 900
QNDFLFSVGE SLSVVAGKWS SKYLIKQIDI PNFNVEIMQQ KFPATNVTTI LDEIFSGCDS 960
TKPSLRKASC IWLLSYIQYL GHLPEVSSKC NDIHLRFMRF LADRDEFIQD SAARGLSLVY 1020
EIGGSDLKES MVKGLLKSFT ESTAGSASTS ATGISGSVSE ETELFEPGVL NTGDGSISTY 1080
KDILNLASEV GDPALVYKFM SLAKSSALWS SRKGIAFGLG AIMSKSSLEE LLLKDQQTAK 1140
KLIPKLYRYR FDPFQAVSRS MTDIWNTLIP ESSLTISLYF NDILDELLCG MANKEWRVRE 1200
ASTSALLQLI QSQPQEKFSE KMLKIWTMAF RTMDDIKDSV REVGTKFTTV LAKILARSID 1260
VEKGVNPTKS KEILDNILPF LWGPHGLNSD AEEVRNFALT TLIDLVKHSP GAIKPFTPKL 1320
IYDFITLFSS IEPQVINYLA LNAANYNIDA NVIDTQRKNG VTNSPLFQTI EKLINNSDDC 1380
MMEEIINVVI KASRKSVGLP SKVASSLVII ILVKRYSIEM KPYSGKLLKV CLTMFEDRNE 1440
SVNIAFAISM GYLFKVSALD KCIKYSEKLI TKYFEPTSTE NNKKVVGTAI DSILNYAKSE 1500
FDNVASVFMP LIFIACNDED KDLETLYNKI WTEASSSGAG TVKLYLPEIL NVLCVNIKSN 1560
DFSIRKTCAK SVIQLCGGIN DSIPYPQIVK LFDISREALS GRSWDGKEHI VAALVSLTEK 1620
FSQTVADNND LQESINHVMY TEVSRKSMKY VKKILPLYAR YINVNPQEET ITFLIEKAKE 1680
MIRLLGSESD DSEGSIKQTS DESTIKRIKP NTEITQKSSK ENIENEEYVI NLLKVSVDIC 1740
NNSKSRYPMN LLEFIIDEIA YLFHNDRIIH TWRTQLAASE IGISIVGRFS TISSADFIQN 1800
VGRLWDQTFP INCNKETIEN VKLQMIKFGG LIIQKIPSLQ NNIEENLRLL NSIDSTSRIE 1860
LELKNIGL 1868 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |