UniProt Accession

 AT2A2_MOUSE; O55143; Q9R2A9; Q9WUT5 

Genbank Protein ID

 AJ131821; AJ223584; AF029982; AJ131870; AJ131870; BC054531; BC054748 

Genbank Nucleotide ID

 CAB72436.1; CAA11450.1; AAD01889.1; CAB41017.1; CAB41018.1; AAH54531.1; AAH54748.1 

Protein Name

 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 

Protein Synonyms/Alias

 SERCA2; SR Ca(2+)-ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase 

Gene Name

 Atp2a2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
996	NYLEQPGKECVQPAT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle (By similarity). 

Sequence Annotation

 REGION 370 400 Interacts with phospholamban 1 (By
 REGION 575 594 Interacts with HAX1 (By similarity).
 REGION 787 807 Interacts with phospholamban 2 (By
 ACT_SITE 351 351 4-aspartylphosphate intermediate (By
 METAL 304 304 Calcium 2; via carbonyl oxygen (By
 METAL 305 305 Calcium 2; via carbonyl oxygen (By
 METAL 307 307 Calcium 2; via carbonyl oxygen (By
 METAL 309 309 Calcium 2 (By similarity).
 METAL 702 702 Magnesium (By similarity).
 METAL 706 706 Magnesium (By similarity).
 METAL 767 767 Calcium 1 (By similarity).
 METAL 770 770 Calcium 1 (By similarity).
 METAL 795 795 Calcium 2 (By similarity).
 METAL 798 798 Calcium 1 (By similarity).
 METAL 799 799 Calcium 1 (By similarity).
 METAL 799 799 Calcium 2 (By similarity).
 METAL 907 907 Calcium 1 (By similarity).
 MOD_RES 294 294 Nitrated tyrosine (By similarity).
 MOD_RES 295 295 Nitrated tyrosine (By similarity).
 MOD_RES 537 537 Phosphothreonine.
 MOD_RES 663 663 Phosphoserine.
 CROSSLNK 143 143 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; ATP-binding; Calcium; Calcium transport; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Hydrolase; Ion transport; Isopeptide bond; Magnesium; Membrane; Metal-binding; Nitration; Nucleotide-binding; Phosphoprotein; Reference proteome; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1044 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0016529; C:sarcoplasmic reticulum; IDA:MGI.
 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005388; F:calcium-transporting ATPase activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006874; P:cellular calcium ion homeostasis; IDA:MGI.
 GO:0006984; P:ER-nucleus signaling pathway; IMP:MGI.
 GO:0045822; P:negative regulation of heart contraction; IGI:MGI.
 GO:0006937; P:regulation of muscle contraction; TAS:MGI.
 GO:0002026; P:regulation of the force of heart contraction; IGI:MGI. 

Interpro

 IPR005782; ATPase_P-typ_Ca-transp_IIA.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 

Pfam

 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 

SMART

 SM00831; Cation_ATPase_N 

PROSITE

 PS00154; ATPASE_E1_E2 

PRINTS

 PR00119; CATATPASE.
 PR00120; HATPASE.