CPLM-011981

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-011981

UniProt Accession

COASY_HUMAN; Q13057; B2RA78; B4DLU0; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3

Genbank Protein ID

AF453478; AY094602; AK075415; AK297153; AK314076; AC067852; CH471152; BC006354; BC020985; BC067254; AF208536; U18919; BT007168

Genbank Nucleotide ID

AAL50813.1; AAM19996.1; BAG59652.1; BAG36775.1; EAW60840.1; AAH06354.1; AAH20985.1; AAH67254.1; AAF87955.1; AAA69699.1; AAP35832.1

Protein Name

Bifunctional coenzyme A synthase

Protein Synonyms/Alias

CoA synthase; NBP; POV-2; Phosphopantetheine adenylyltransferase; Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT; Dephospho-CoA kinase; DPCK; Dephosphocoenzyme A kinase; DPCOAK

Gene Name

COASY

Gene Synonyms/Alias

PSEC0106

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
235	DKDLLKSKLLPELLQ	ubiquitination	[1]
554	KAWALLQKRIPKTHQ	ubiquitination	[1]

Reference

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]

Functional Description

Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.

Sequence Annotation

DOMAIN 360 563 DPCK.
NP_BIND 365 372 ATP (Potential).
REGION 180 358 Phosphopantetheine adenylyltransferase.
MOD_RES 178 178 Phosphoserine.
MOD_RES 183 183 Phosphoserine.

Keyword

Alternative splicing; ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; Kinase; Multifunctional enzyme; Nucleotide-binding; Nucleotidyltransferase; Phosphoprotein; Polymorphism; Reference proteome; Transferase.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

564 AA

Protein Sequence

MAVFRSGLLV LTTPLASLAP RLASILTSAA RLVNHTLYVH LQPGMSLEGP AQPQSSPVQA 60
TFEVLDFITH LYAGADVHRH LDVRILLTNI RTKSTFLPPL PTSVQNLAHP PEVVLTDFQT 120
LDGSQYNPVK QQLVRYATSC YSCCPRLASV LLYSDYGIGE VPVEPLDVPL PSTIRPASPV 180
AGSPKQPVRG YYRGAVGGTF DRLHNAHKVL LSVACILAQE QLVVGVADKD LLKSKLLPEL 240
LQPYTERVEH LSEFLVDIKP SLTFDVIPLL DPYGPAGSDP SLEFLVVSEE TYRGGMAINR 300
FRLENDLEEL ALYQIQLLKD LRHTENEEDK VSSSSFRQRM LGNLLRPPYE RPELPTCLYV 360
IGLTGISGSG KSSIAQRLKG LGAFVIDSDH LGHRAYAPGG PAYQPVVEAF GTDILHKDGI 420
INRKVLGSRV FGNKKQLKIL TDIMWPIIAK LAREEMDRAV AEGKRVCVID AAVLLEAGWQ 480
NLVHEVWTAV IPETEAVRRI VERDGLSEAA AQSRLQSQMS GQQLVEQSHV VLSTLWEPHI 540
TQRQVEKAWA LLQKRIPKTH QALD 564

Gene Ontology

GO:0005741; C:mitochondrial outer membrane; TAS:Reactome.
GO:0005634; C:nucleus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0004140; F:dephospho-CoA kinase activity; IDA:UniProtKB.
GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IDA:UniProtKB.
GO:0015937; P:coenzyme A biosynthetic process; IDA:UniProtKB.
GO:0015939; P:pantothenate metabolic process; TAS:Reactome.

Interpro

IPR004821; Cyt_trans-like.
IPR001977; Depp_CoAkinase.
IPR027417; P-loop_NTPase.
IPR014729; Rossmann-like_a/b/a_fold.

Pfam

PF01121; CoaE
PF01467; CTP_transf_2

SMART

PROSITE

PS51219; DPCK

PRINTS