UniProt Accession

 STIP1_RAT; O35814 

Genbank Protein ID

 Y15068; BC061529 

Genbank Nucleotide ID

 CAA75351.1; AAH61529.1 

Protein Name

 Stress-induced-phosphoprotein 1 

Protein Synonyms/Alias

 STI1; Hsc70/Hsp90-organizing protein; Hop 

Gene Name

 Stip1 

Gene Synonyms/Alias

 Hop 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
8	MEQVNELKEKGNKAL	acetylation	[1]
68	GCKTVDLKPDWGKGY	acetylation	[1]
73	DLKPDWGKGYSRKAA	acetylation	[1]
100	RTYEEGLKHEANNLQ	acetylation	[1]
162	LIEQLQNKPSDLGTK	acetylation	[1]
162	LIEQLQNKPSDLGTK	ubiquitination	[2]
229	KKQALKEKELGNDAY	acetylation	[1]
243	YKKKDFDKALKHYDK	acetylation	[1]
312	RIGNSYFKEERYKDA	acetylation	[1]
317	YFKEERYKDAIHFYN	acetylation	[1]
325	DAIHFYNKSLAEHRT	acetylation	[1]
337	HRTPDVLKKCQQAEK	acetylation	[1]
347	QQAEKILKEQERLAY	acetylation	[1]
364	PDLALEEKNKGNECF	acetylation	[1]
395	KRNPRDAKLYSNRAA	acetylation	[1]
442	AAALEAMKDYTKAMD	acetylation	[1]
446	EAMKDYTKAMDVYQK	acetylation	[1]
513	LILEQMQKDPQALSE	acetylation	[1]
530	KNPVIAQKIQKLMDV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB). 

Sequence Annotation

 REPEAT 4 37 TPR 1.
 REPEAT 39 71 TPR 2.
 REPEAT 73 105 TPR 3.
 DOMAIN 130 169 STI1 1.
 REPEAT 225 258 TPR 4.
 REPEAT 260 292 TPR 5.
 REPEAT 300 333 TPR 6.
 REPEAT 360 393 TPR 7.
 REPEAT 395 427 TPR 8.
 REPEAT 428 461 TPR 9.
 DOMAIN 492 531 STI1 2.
 MOTIF 222 239 Bipartite nuclear localization signal
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 8 8 N6-acetyllysine (By similarity).
 MOD_RES 16 16 Phosphoserine (By similarity).
 MOD_RES 301 301 N6-acetyllysine (By similarity).
 MOD_RES 312 312 N6-acetyllysine (By similarity).
 MOD_RES 325 325 N6-acetyllysine (By similarity).
 MOD_RES 344 344 N6-acetyllysine (By similarity).
 MOD_RES 354 354 Phosphotyrosine (By similarity).
 MOD_RES 446 446 N6-acetyllysine (By similarity).
 MOD_RES 481 481 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 543 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:RGD. 

Interpro

 IPR006636; STI1_HS-bd.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF00515; TPR_1
 PF13181; TPR_8 

SMART

 SM00727; STI1
 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS