CPLM-027953

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-027953

UniProt Accession

Genbank Protein ID

AF145306; AE014298; BT046144; FN544098; FN544099; FN544100; FN544101; FN544102; FN544103; FN544104; FN544105; FN544106; FN544108

Genbank Nucleotide ID

AAF08387.1; AAF48001.1; ACI46532.1; CBA35179.1; CBA35180.1; CBA35181.1; CBA35182.1; CBA35183.1; CBA35184.1; CBA35185.1; CBA35186.1; CBA35187.1; CBA35189.1

Protein Name

26S proteasome regulatory complex subunit p48A

Protein Synonyms/Alias

CG16916 protein; GH06151p; Regulatory particle triple-A ATPase 3

Gene Name

Rpt3

Gene Synonyms/Alias

Rpt3-RA; CG16916; Dmel_CG16916

Created Date

July 27, 2013

Organism

Drosophila melanogaster (Fruit fly)

NCBI Taxa ID

7227

Lysine Modification

Position	Peptide	Type	References
233	VGSEFVQKYLGEGPR	acetylation	[1]
392	NRYIVLAKDFEKGYK	acetylation	[1]
396	VLAKDFEKGYKNNIK	acetylation	[1]

Reference

[1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702]

Functional Description

Sequence Annotation

Keyword

ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding; Proteasome; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

413 AA

Protein Sequence

MPYNMDVLIP EKDELSDLKL KDAHSSLDEL DMEDLYVRYK KLQKTLEFIE VQEEYIKDEQ 60
RNLKKEYLHA QEEVKRIQSV PLVIGQFLEA VDQNTGIVGS TTGSNYYVRI LSTIDRELLK 120
PSASVALHKH SNALVDVLPP EADSSISMLQ PDEKPDVSYA DIGGMDMQKQ EIREAVELPL 180
THFELYKQIG IDPPRGVLMY GPPGCGKTML AKAVAHHTTA SFIRVVGSEF VQKYLGEGPR 240
MVRDVFRLAK ENAPAIIFID EIDAIATKRF DAQTGADREV QRILLELLNQ MDGFDQTTNV 300
KVIMATNRAD TLDPALLRPG RLDRKIEFPL PDRRQKRLVF STITSKMNLS EDVDLEEFVA 360
RPDKISGADI NAICQEAGMH AVRENRYIVL AKDFEKGYKN NIKKDEQEHE FYK 413

Gene Ontology

GO:0005737; C:cytoplasm; IEA:InterPro.
GO:0001673; C:male germ cell nucleus; IDA:FlyBase.
GO:0008540; C:proteasome regulatory particle, base subcomplex; ISS:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; IEA:EC.
GO:0006200; P:ATP catabolic process; IEA:GOC.
GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:FlyBase.
GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.

Interpro

IPR005937; 26S_Psome_P45.
IPR003593; AAA+_ATPase.
IPR003959; ATPase_AAA_core.
IPR003960; ATPase_AAA_CS.
IPR001270; Chaprnin_ClpA/B.
IPR027417; P-loop_NTPase.

Pfam

PF00004; AAA

SMART

SM00382; AAA

PROSITE

PS00674; AAA

PRINTS

PR00300; CLPPROTEASEA.