UniProt Accession

 DEDD_HUMAN; O75618; D3DVF5; O60737 

Genbank Protein ID

 AF083236; AF100341; AF043733; AJ010973; AF064605; CR536556; AL591806; CH471121; CH471121; CH471121; CH471121; CH471121; BC016724; BC013910 

Genbank Nucleotide ID

 AAC33105.1; AAD16414.1; AAC80280.1; CAA09445.1; AAC17110.3; CAG38793.1; CAI15381.1; EAW52648.1; EAW52650.1; EAW52651.1; EAW52652.1; EAW52653.1; AAH16724.1; AAH13910.1 

Protein Name

 Death effector domain-containing protein 

Protein Synonyms/Alias

 DEDPro1; Death effector domain-containing testicular molecule; FLDED-1 

Gene Name

 DEDD 

Gene Synonyms/Alias

 DEDPRO1; DEFT; KE05 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
237	NQANTILKSRDLGSI	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). 

Sequence Annotation

 DOMAIN 25 103 DED.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0046697; P:decidualization; IEA:Compara.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; TAS:ProtInc.
 GO:0006917; P:induction of apoptosis; ISS:UniProtKB.
 GO:0042177; P:negative regulation of protein catabolic process; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR001875; DED. 

Pfam

 PF01335; DED 

SMART

 SM00031; DED 

PROSITE

 PS50168; DED 

PRINTS